Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).

Cardiovascular risk factors linked to choroidal thinning

29 Oct 2020
Gene therapy is said to help restore vision loss due to a condition known as choroidermia.

Cardiovascular risk factors (CVRFs), such as lipid profile and blood pressure, may promote the thinning of choroidal thickness (CT), a recent study has shown.

The researchers conducted a cross-sectional, prospective observational study including 92 patients with CVRFs. Participants were divided into four groups according to the SCORE system: group 1 (n=30), with mild CVR; group 2 (n=30), with moderate CVR; group 3 (n=10), with high CVR; and group 4 (n=24), with coronary artery disease (CAD). Twenty-one healthy controls were also included.

The mean subfoveal CT (SFCT) was significantly lower in all study groups, on both eyes, relative to the healthy controls. For groups 2 to 4, CT in both eyes was likewise significantly thinner at every nasal and temporal determination.

Notably, central macular thickness (CMT) in both eyes did not seem to differ between all study groups and healthy controls.

In both study and control groups, SFCT, CMT, and CT at all nasal and temporal determinations were inversely correlated with age. Levels of low-density lipoprotein cholesterol were likewise inversely associated with SFCT in both eyes.

“These findings suggest that CT may represent a promising and reassuring disease marker before the development of CAD that may be able to provide crucial information regarding both systemic cardiovascular health and susceptibility to disease of the outer retina, retinal pigment epithelium, and choroid,” the researchers said.

However, clinical trials with longer follow-ups and larger sample sizes will be needed in the future to more definitively understand the effect of CVRFs on the retina and choroid, they added.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).