Most Read Articles
Pearl Toh, 5 days ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 20 Oct 2020
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Yesterday
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.

Cardiometabolic multimorbidity tied to worse outcomes, bleeding in AF patients

13 Oct 2020

Atrial fibrillation (AF) patients with cardiometabolic multimorbidity appear to experience worse outcomes and severe bleeding, a study has found.

The investigators identified patients with nonvalvular AF aged ≥75 years in the Market Scan Medicare Supplemental database from 2007–2015. They obtained the prevalence of 14 chronic conditions at the time of AF diagnosis and classified these as either cardiometabolic or noncardiometabolic.

Cox regression was used to estimate the associations of the number and type of conditions with stroke, severe bleeding, and heart failure hospitalizations. Tests for interaction were also examined between AF treatments and multimorbidity.

Overall, 275,617 patients with AF (mean age, 83 years; 51 percent women) were included; each participant had a mean of 3.0 conditions. A total of 7,814 strokes, 13,622 severe bleeds, and 19,252 heart failure events occurred over a mean follow-up of 23 months.

After adjustment, increases in the number of cardiometabolic conditions correlated with a higher risk of stroke (hazard ratio [HR], 1.07, 95 percent confidence interval [CI], 1.05–1.10), severe bleeding (HR, 1.09, 95 percent CI, 1.07–1.11), and heart failure (HR, 1.19, 95 percent CI, 1.18–1.20).

On the other hand, the number of noncardiometabolic conditions showed weak or null associations with the risk of cardiovascular endpoints.

The effectiveness of AF treatment on stroke and heart failure, in general, was similar across multimorbidity status. However, patients with overall and subgroup multimorbidity had higher bleeding risk associated with AF treatments.

“These findings underscore the impact of cardiometabolic conditions on AF outcomes and highlight the need to incorporate multimorbidity management in AF treatment guidelines,” the investigators said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 5 days ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 20 Oct 2020
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Yesterday
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.