Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
09 Jan 2020
Acute ischaemic stroke patients who are current or recent smokers are at greater odds of having unfavourable functional outcomes 3 months after the index event, a study has found.
Stephen Padilla, 3 days ago
Brodalumab has exhibited long-term efficacy and consistent safety profile for more than 2 years in the treatment of patients with psoriasis, results of the phase III AMAGINE-2 trial show.

Cardiac magnetic resonance findings predict rhythm disturbances in scleroderma

14 Jan 2020

Oedema (T2 ratio) and late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) are highly predictive of rhythm disturbances in patients with systemic sclerosis (SSc), a study has found.

Researchers used data from the Scleroderma Arrhythmia Clinical Utility Study (SAnCtUS), a prospective multicentre study involving 150 consecutive SSc patients (mean age, 54.3 years; 84 percent female) from eight European centres. They translated 24-hour Holter findings into a tangible risk prediction score using CMR.

In the cohort, 108 (73.4 percent), 128 (87.1 percent) and 36 (24.5 percent) patients used immunomodulatory, cardiovascular and antiplatelet medication, respectively. Median left ventricular ejection fraction (LVEF) was 64.5 percent, with LVEF <50 percent in eight (5.3 percent) patients and 35 percent in two (1.3 percent) patients.

Seventy-three (48.7 percent) patients had one or more rhythm disturbances of any type, among whom 20 had at least one type of supraventricular rhythm disturbance and 68 at least one type of ventricular rhythm disturbance. There was one patient with atrioventricular block, while another had pulmonary hypertension.

Of the CMR indices, only T2 ratio and LGE emerged as significant predictors of ventricular rhythm disturbances, but not of supraventricular rhythm disturbances, in multivariable logistic regression models. The researchers then created a four-category scoring system (the SAnCtUS score) based on T2 ratio and LGE for identifying SSc patients at high risk of experiencing ventricular rhythm disturbance at baseline.

Higher SAnCtUS scores correlated with a greater disease and arrhythmic burden. All cases of nonsustained ventricular tachycardia (n=7) occurred in the group of patients with the highest SAnCtUS score (4). Compared with lower scores, the highest score was associated with a heightened risk of the combined endpoint of sustained ventricular tachycardia requiring hospitalization and sudden cardiac death at a median follow-up of 1 year (hazard ratio, 3.86, 95 percent confidence interval, 1.14–13.04; p=0.029), independent of LVEF and the presence of ventricular tachycardia at baseline.

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
09 Jan 2020
Acute ischaemic stroke patients who are current or recent smokers are at greater odds of having unfavourable functional outcomes 3 months after the index event, a study has found.
Stephen Padilla, 3 days ago
Brodalumab has exhibited long-term efficacy and consistent safety profile for more than 2 years in the treatment of patients with psoriasis, results of the phase III AMAGINE-2 trial show.