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04 Oct 2020
Obesity does not appear to be strongly correlated with an increased risk for febrile neutropaenia during levofloxacin prophylaxis in patients with haematological malignancies receiving intermediate-risk myelosuppressive chemotherapy, suggests a study.
Roshini Claire Anthony, 2 days ago

Initiation or switch to the single-tablet regimen of bictegravir/emtricitabine/tenofovir alafenamide (TAF) led to low HIV-1 RNA viral load in people living with HIV (PLHIV), according to the BICSTaR study presented at HIV Glasgow 2020.

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Use of corticosteroids appears to be an effective treatment for paediatric drug reaction with eosinophilia and systemic symptoms (DRESS), suggest the results of a recent study. In severe cases, corticosteroids used in conjunction with intravenous immunoglobulin result in fast clinical improvement.
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Carbamazepine, valproic acid may pose increased stroke risk in bipolar patients

22 Jul 2019

Mood stabilizers for bipolar disorder are implicated in the risk of stroke, which appears to vary among the different types of drugs, as suggested in a recent study. Carbamazepine carries the highest risk of stroke, followed by valproic acid, whereas lithium and lamotrigine have a null effect.

The study used data from the Taiwan National Health Insurance Research Database and identified 19,433 patients with bipolar disorder. Of these, 609 developed stroke. Researchers applied 14-day windows to evaluate the acute exposure effect of individual mood stabilizers on the risk of ischaemic, haemorrhagic and other types of stroke in the study population.

Mood stabilizers overall were associated with about a 20-percent increase in stroke risk (adjusted risk ratio, 1.26; p=0.041).

On separate analysis, acute exposure to carbamazepine posed the highest risk of stroke (adjusted risk ratio [RR], 1.68; p=0.018), especially the ischaemic type (adjusted RR, 1.81; p=0.037). Acute exposure to valproic acid, on the other hand, was associated with a heightened risk of haemorrhagic stroke (adjusted RR, 1.76; p=0.022).

Acute exposure to neither lithium nor lamotrigine significantly increased the risk of any type of stroke.

The current data may be used as a guide for choosing which mood stabilizers to use in the management of patients with bipolar disorder who require acute therapy for affective symptoms and who already have the risk factors for stroke, according to the researchers.

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Most Read Articles
04 Oct 2020
Obesity does not appear to be strongly correlated with an increased risk for febrile neutropaenia during levofloxacin prophylaxis in patients with haematological malignancies receiving intermediate-risk myelosuppressive chemotherapy, suggests a study.
Roshini Claire Anthony, 2 days ago

Initiation or switch to the single-tablet regimen of bictegravir/emtricitabine/tenofovir alafenamide (TAF) led to low HIV-1 RNA viral load in people living with HIV (PLHIV), according to the BICSTaR study presented at HIV Glasgow 2020.

09 Nov 2020
Use of corticosteroids appears to be an effective treatment for paediatric drug reaction with eosinophilia and systemic symptoms (DRESS), suggest the results of a recent study. In severe cases, corticosteroids used in conjunction with intravenous immunoglobulin result in fast clinical improvement.
07 Aug 2020
Concomitant treatment with a nonsteroidal anti-inflammatory drug (NSAID) following myocardial infarction (MI) is associated with a higher risk of cardiovascular and bleeding events, a study has shown.