Most Read Articles
Rachel Soon, 2 days ago

On 8 August, the first town hall held by the Ministry of Health (MOH) with members of the pharmacy profession took place in Putrajaya. Over 500 pharmacists from across the country and from different areas of practice—community and hospital, public and private, academy and industry—converged to fill the auditorium for the chance to engage in direct dialogue with MOH.

Jackey Suen, 08 Oct 2018

Adding pertuzumab to trastuzumab plus an aromatase inhibitor (AI) improves progression-free survival (PFS) in patients with HER2-positive metastatic or locally advanced breast cancer, the phase II PERTAIN study has shown.

05 Aug 2019
Use of alpha blockers in the treatment of hypertension in women is associated with an increased risk of hypotension and related events as compared with other blood pressure-lowering drugs, as reported in a recent study.
Laura Kho Sui San , 29 May 2019
Anxiety becomes a pathological disorder when it occurs for no detectable reason, persists and interferes with daily activities like work performance and relationships.

Carbamazepine, valproic acid may pose increased stroke risk in bipolar patients

22 Jul 2019

Mood stabilizers for bipolar disorder are implicated in the risk of stroke, which appears to vary among the different types of drugs, as suggested in a recent study. Carbamazepine carries the highest risk of stroke, followed by valproic acid, whereas lithium and lamotrigine have a null effect.

The study used data from the Taiwan National Health Insurance Research Database and identified 19,433 patients with bipolar disorder. Of these, 609 developed stroke. Researchers applied 14-day windows to evaluate the acute exposure effect of individual mood stabilizers on the risk of ischaemic, haemorrhagic and other types of stroke in the study population.

Mood stabilizers overall were associated with about a 20-percent increase in stroke risk (adjusted risk ratio, 1.26; p=0.041).

On separate analysis, acute exposure to carbamazepine posed the highest risk of stroke (adjusted risk ratio [RR], 1.68; p=0.018), especially the ischaemic type (adjusted RR, 1.81; p=0.037). Acute exposure to valproic acid, on the other hand, was associated with a heightened risk of haemorrhagic stroke (adjusted RR, 1.76; p=0.022).

Acute exposure to neither lithium nor lamotrigine significantly increased the risk of any type of stroke.

The current data may be used as a guide for choosing which mood stabilizers to use in the management of patients with bipolar disorder who require acute therapy for affective symptoms and who already have the risk factors for stroke, according to the researchers.

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Most Read Articles
Rachel Soon, 2 days ago

On 8 August, the first town hall held by the Ministry of Health (MOH) with members of the pharmacy profession took place in Putrajaya. Over 500 pharmacists from across the country and from different areas of practice—community and hospital, public and private, academy and industry—converged to fill the auditorium for the chance to engage in direct dialogue with MOH.

Jackey Suen, 08 Oct 2018

Adding pertuzumab to trastuzumab plus an aromatase inhibitor (AI) improves progression-free survival (PFS) in patients with HER2-positive metastatic or locally advanced breast cancer, the phase II PERTAIN study has shown.

05 Aug 2019
Use of alpha blockers in the treatment of hypertension in women is associated with an increased risk of hypotension and related events as compared with other blood pressure-lowering drugs, as reported in a recent study.
Laura Kho Sui San , 29 May 2019
Anxiety becomes a pathological disorder when it occurs for no detectable reason, persists and interferes with daily activities like work performance and relationships.