Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 5 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.

Carbamazepine, lamotrigine use tied to squamous cell carcinoma

18 Jan 2020
Skin cancer is among the top 10 cancers for men and women in Singapore

Treatment with antiepileptic drugs does not increase the risk of skin cancer, but an association has been observed between use of carbamazepine and lamotrigine and squamous cell carcinoma (SCC), a recent study has shown.

Most antiepileptic drugs did not correlate with skin cancer. However, SCC was associated with use of carbamazepine (odds ratio [OR], 1.88, 95 percent confidence interval [CI], 1.42–2.49) and lamotrigine (OR, 1.57, 95 percent CI, 1.12–2.22), with evidence of a dose-response relationship for carbamazepine.

Nonetheless, the estimated absolute risks appeared to be low. For one additional SCC to occur, 6,335 person-years of high cumulative exposure to carbamazepine were needed.

“These findings need to be replicated and characterized further in other settings and have no direct clinical implications,” the investigators said.

This nested case-control study was conducted to examine the association of common antiepileptic drugs, which are known to be photosensitizing, with basal cell carcinoma, SCC and malignant melanoma. Skin cancer patients in Denmark were identified from 2004–2015 and matched 1:10 with disease-free controls. The investigators estimated ORs for skin cancer associated with high cumulative use of antiepileptic drugs (≥500 defined daily doses) compared with nonuse.

The study was limited by the absence of data on important risk factors for skin cancer, such as sun exposure, according to the investigators.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 5 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.