Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 2 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 3 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.

Candidaemia, comorbidities most prevalent among neonates

25 Apr 2019

There is a high incidence of candidaemia and a substantial burden of comorbidities among neonates as confirmed in a recent nationwide epidemiologic study of paediatric candidaemia. An increasing proportion of nonalbicans species resistant to fluconazole has also been observed.

The investigators identified 153 paediatric patients (aged ≤15 years) with 158 candidaemia episodes. Overall annual incidence rate was 1.3 per 100,000 population, with higher rates for neonates (5.7 per 100,000 live births) and low birth weight neonates (103.8 per 100,000 live births).

The proportion of Candida albicans from 2004–2009 to 2010–2014 showed a reduction from 74.4 percent to 64.7 percent. On the other hand, resistance to fluconazole increased from 7.8 percent to 17.7 percent.

At least one underlying disease was present in almost all patients (98.6 percent), and multimorbidity was common (43.5 percent; ≥2 underlying diseases). These underlying diseases varied by age, with heart malformations and gastrointestinal disease prevalent in children <3 years old.

Overall mortality rate for 30 days stood at 10.2 percent, with the highest proportion recorded among neonates (17.1 percent). An upsurge in mortality was observed from 2004 to 2010 to 2014 due to an increase among older children.

“Our findings underline the importance of choosing correct treatment and continuous surveillance of paediatric candidaemia,” the investigators said.

In this nationwide cohort study, all candidaemia episodes were identified through the active nationwide fungemia surveillance program. The EUCAST E.Def 7 (European Committee on Antifungal Susceptibility Testing, Edition Definitive) reference method was followed by susceptibility testing. The following were used for statistical analyses: χ2 test, Fisher exact test and Venn diagrams.

“Candidemia is the most frequent paediatric fungal infection but incompletely elucidated in population-based settings,” the investigators said.

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Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 2 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 3 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.