Most Read Articles
Pearl Toh, 15 Jul 2019
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from the large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
2 days ago
Health-related quality of life (HRQoL) among patients with kidney stone is worse in those who are young and female than those who are older and male, according to a recent study. Non-Caucasian patients also have a lower HRQoL.
Tristan Manalac, 3 days ago
In patients with ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PPCI), admission Killip classification and creatinine and troponin levels are important cardiac mortality predictors, according to a recent Singapore study.

Cancer symptom burden in seniors correlates with functional impairment

21 Mar 2019

Higher cancer symptom burden in elderly adults is associated with functional impairment, reports a recent study.

The study included 359 elderly cancer patients (median age 81 years; 54.0 percent male) in whom symptom burden was measured using the Clinical Symptom Inventory. Functional impairment was assessed according to instrumental activities of daily living (IADL), the Short Physical Performance Battery (SPPB) or the Medical Outcomes Survey.

Almost half of the participants had advanced malignancy. At baseline, 69 percent had had prior surgery, 41 percent had received radiation and 32 percent had undergone chemotherapy. The majority (70 percent) had noncancer comorbidities, such as high blood pressure (59 percent) and arthritis (58 percent), as well as physical activity limitations (77.81 percent).

The highest vs lowest quartile of symptom burden was associated with significantly elevated rates of IADL impairment (91 percent vs 51 percent), physical activity limitation (93 percent vs 65 percent) and falls (55 percent vs 21 percent; p<0.01 for all).

Moreover, there was a significantly higher proportion of patients with SPPB score ≤9 in the topmost vs bottom quartile of symptom burden (92 percent vs 69 percent; p<0.01).

Bivariate logistic regression analysis further confirmed the link between symptom burden and physical function impairments. For instance, patients who were independent with IADLs reported lower symptom scores than those who required assistance (12.89±13.41 vs 27.97±21.47; p<0.001).

The same was true for physical activity (lower vs higher symptom burden: 12.58±13.11 vs 26.36±20.98; p<0.001) and falls (19.01±19.03 vs 29.89±20.95; p<0.001). 
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Most Read Articles
Pearl Toh, 15 Jul 2019
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from the large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
2 days ago
Health-related quality of life (HRQoL) among patients with kidney stone is worse in those who are young and female than those who are older and male, according to a recent study. Non-Caucasian patients also have a lower HRQoL.
Tristan Manalac, 3 days ago
In patients with ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PPCI), admission Killip classification and creatinine and troponin levels are important cardiac mortality predictors, according to a recent Singapore study.