Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Pearl Toh, 6 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Elvira Manzano, 17 Nov 2020
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.

CALM intervention not superior to routine supportive psycho-oncological care

14 Sep 2020

While the Managing Cancer and Living Meaningfully (CALM) therapy leads to improvements in depressive symptoms over time, it does not appear to be better than supportive psycho-oncological counselling intervention (SPI), a new trial has found.

“CALM is a brief, semi-structured, individual, psychotherapeutic intervention and has been shown to be effective in alleviating depression, and enhancing hope and meaning in life,” researchers said.

In the present study, patients assigned to the CALM (n=99) or SPI (n=107) arms received a comparable number of sessions, as well as underwent a similar length of treatment. Both CALM and SPI therapists reported low adherence scores.

In both groups, depressive symptoms dropped significantly 6 months after randomization relative to baseline (p<0.001). However, at the same time point, no such between-group differences were reported in terms of depression severity, as measured by the Beck Depression Inventory (p=0.62) and Patient Health Questionnaire (p=0.998).

At baseline, CALM participants showed higher levels of attachment insecurity, which persisted until the first follow-up, 3 months after randomization. At this time point, demoralization was likewise significantly elevated in the CALM arm. However, by the final follow-up, 6 months after randomization, both secondary outcome measures were comparable between the CALM and SPI arms.

Contrary to the study hypothesis, CALM did not show superiority to SPI, though this may be due to poor treatment differentiation between the two interventions, the researchers said. “SPI therapists are familiar with psycho-oncological treatment of patients with advanced cancer for several years, thus, the application of core elements that might overlap with CALM therapy is likely.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Oncology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Pearl Toh, 6 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Elvira Manzano, 17 Nov 2020
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.