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01 Dec 2020
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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
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Taking calcium supplements reduces risk of squamous cell carcinoma

30 Dec 2020

Treatment with calcium supplementation with or without vitamin D appears to lower the risk of invasive cutaneous squamous cell carcinoma (SCC) but not basal cell carcinoma (BCC), a study has shown.

The investigators sought to determine whether daily vitamin D or calcium supplementation modifies the risk of BCC or SCC in this multicentre, double-blind, placebo-controlled, partial two-by-two factorial, randomized clinical trial of vitamin D, calcium, or both for the prevention of colorectal adenomas.

A total of 2,259 men and women aged 45–75 years, who were diagnosed with a colorectal adenoma from 2004 to 2008 were randomized to receive 1,000 IU/d of vitamin D3 or placebo and 1,200 mg/d of calcium carbonate or placebo for 3 or 5 years. Participants were followed when treatment ended. Pathology records were used to confirm reports of incident BCC or SCC.

Of the participants, 200 (9 percent) were diagnosed with BCC and 68 (3 percent) with SCC during a median follow-up of 8 years.

BCC incidence was not associated with vitamin D treatment compared with no vitamin D (hazard ratio [HR], 0.96, 95 percent confidence interval [CI], 0.73–1.26), calcium compared with no calcium (HR, 1.01, 95 percent CI, 0.74–1.39), and both agents compared with neither (HR, 0.99, 95 percent CI, 0.65–1.51).

SCC incidence, on the other hand, was not associated with vitamin D treatment compared with no vitamin D (HR, 0.79, 95 percent CI, 0.49–1.27), but there appeared to be beneficial effects for calcium compared with no calcium (HR, 0.60, 95 percent CI, 0.36–1.01) and both agents compared with neither (HR, 0.42, 95 percent CI, 0.19–0.91).

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Yesterday
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.