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01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.

Cabozantinib plus ADT an effective combo in hormone-naïve metastatic prostate cancer

02 Apr 2020

Cabozantinib plus androgen deprivation therapy (ADT) shows potent clinical activity in hormone-naïve metastatic prostate cancer (HNMPCa), according to the results of a phase II trial.

The trial included 62 patients who received ADT plus cabozantinib starting at 60 mg daily (median time from ADT initiation to cabozantinib initiation, 3.3 weeks), among which 46 had de novo metastatic disease and 54 had high-volume disease. Over a median follow-up of 31.2 months, 57 patients (92 percent) discontinued cabozantinib and 50 (81 percent) developed castrate-resistant progression. Common reasons for discontinuation included disease progression in 37 (65 percent) and toxicity in nine (16 percent).

The primary endpoint of castrate-resistant progression-free survival (PFS), assessed by radiographic criteria, clinical progression or receipt of additional therapy, was a median of 16.1 months (95 percent confidence interval, 14.6–22.7). Median overall survival was not reached.

Reductions in prostate specific antigen of ≥90 percent occurred in 50 of 60 patients (83 percent), bone-specific alkaline phosphatase of ≥50 percent were seen in 34 of 39 (87 percent), and urine N-telopeptides of ≥50 percent were recorded in 18 of 21 (86 percent).

Responses in bone scan were observed in 81 percent of 54 patients. Of the 30 patients with RECIST measurable disease (n=30), three (10 percent) achieved stable disease or best response, 18 (60 percent) achieved partial response, and nine (30 percent) achieved complete response.

Frequently reported grade 3 adverse events were hypertension (19 percent), diarrhoea (6 percent) and thromboembolic events (6 percent). Dose reductions occurred in 85 percent of the population.

On analysis of baseline cytokine and angiogenic factors (CAFs), shorter PFS was associated with higher plasma concentrations of Lumican, CXCL5, CD25 and CD30, as well as high tumour expression of pFGFR1.

The present data suggest that CAF profiles and tissue markers may be used as candidate prognostic and predictive markers of cabozantinib benefit in HNMPCa and hence guide rational therapy combinations, researchers said.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.