Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.
18 Apr 2020
Statins appear to be useful as a primary prevention treatment in older adults with hypercholesterolaemia, reports a new meta-analysis.

CABG outperforms PCI in diabetics with multivessel disease

20 Oct 2019

Coronary artery bypass graft (CABG) leads to better long-term survival than percutaneous coronary intervention (PCI) in unselected type 2 diabetes patients, a recent study has found.

Researchers enrolled 430 diabetes mellitus patients with multivessel disease determined through angiographic screening. At a median of 6 years, the overall rate for all-cause mortality was 25 percent. This was significantly greater in those who underwent CABG vs PCI or who had no revascularization (16 percent vs 26 percent and 33 percent; p=0.009).

Those who received CABG also had the lowest rate of nonfatal myocardial infarction relative to other procedures (p=0.016). The same was true for the composite endpoint of death, stroke and myocardial infarction (p<0.001).

Multivariable analysis further showed that not undergoing CABG was a significant risk factor for late mortality, as were older age and hypertension. In comparison, presenting with acute coronary syndrome and triple vessel disease were significantly associated with greater risks of late myocardial infarction.

The composite endpoint, on the other hand, was correlated triple vessel disease, acute coronary syndrome and not undergoing any revascularization procedures.

Subsequent propensity analyses found that those treated with PCI showed significantly higher rates of mortality (hazard ratio [HR], 1.94, 95 percent CI, 1.02–3.70; p=0.045), myocardial infarction (HR, 2.87, 1.12–7.31; p=0.028) and of the composite outcome (HR, 1.80, 1.11–2.92; p=0.017) than their CABG counterparts. These trends held up in multivariable Cox regression analysis.

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Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.
18 Apr 2020
Statins appear to be useful as a primary prevention treatment in older adults with hypercholesterolaemia, reports a new meta-analysis.