Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).

Bronchiectasis preceding ANCA-related vasculitis onset tied to shorter survival

30 Oct 2020

The association between bronchiectasis and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) does not appear to be incidental and is mostly correlated with myeloperoxidase (MPO)-ANCA, suggests a recent study.

In addition, patients in whom bronchiectasis precedes the onset of AAV “tend to have distinct clinical and biological features and could carry a worse prognosis,” the authors said.

This retrospective nationwide multicentre study reported on a large series of patients diagnosed with AAV and bronchiectasis, with a specific focus on the timeline of occurrence of both features.

Sixty-one patients participated in this study, of whom 27 (44.25 percent) had microscopic polyangiitis (MPA), 27 (44.25 percent) had granulomatosis with polyangiitis (GPA), and seven (11.5 percent) had eosinophilic GPA. In addition, 39 patients (64 percent) had MPO-ANCA and 13 (21 percent) had proteinase 3–ANCA.

The diagnosis of bronchiectasis in these patients either preceded (n=25; median time between both diagnoses, 16 years; interquartile range [IQR], 4–54 years), was concomitant to (n=12), or followed that of AAV (n=24; median time between both diagnoses, 1 years; IQR, 0–6 years). Patients with a bronchiectasis diagnosis that preceded AAV onset had more frequent mononeuritis multiplex, MPA, MPO-ANCA, and a fivefold increase of death.

Of note, AAV relapse appeared to have a protective effect against bronchiectasis worsening (hazard ratio [HR], 0.6, 95 percent confidence interval [CI], 0.4–0.99; p=0.049) in this population. On the other hand, a bronchiectasis diagnosis prior to AAV (HR, 5.8, 95 percent CI, 1.2–28.7; p=0.03) or MPA (HR, 18.1, 95 percent CI, 2.2–146.3; p=0.01) correlated with shorter survival during AAV follow-up.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).