Most Read Articles
Roshini Claire Anthony, 2 days ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 5 days ago
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
3 days ago
The simple Atrial fibrillation (AF) Better Care (ABC) pathway holistically updates the integrated care for AF patients and helps reduce the risk of adverse outcomes such as all-cause mortality, stroke/major bleeding/cardiovascular death and hospitalization, according to a study.
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Type 1 diabetes impairs cognitive functioning in children, and this effect is exacerbated by extreme glycaemic levels, according to a recent meta-analysis.

Bright white light therapy improves depression in patients with bipolar disorder

11 Feb 2018

Use of midday bright light therapy is effective in patients with bipolar depression, suggests a study.

A 6-week randomized, double-blind, placebo-controlled trial was conducted to assess the efficacy of adjunctive bright light therapy at midday for bipolar depression. Depressed adults with bipolar I or II disorder who were receiving stable dosages of antimanic medication (excluding those with hypomania or mania, mixed symptoms, or rapid cycling) were randomly assigned to either 7,000-lux bright white light or 50-lux dim red placebo light (n=23 for each group).

The investigators used the Structured Interview Guide for the Hamilton Depression Scale With Atypical Depression Supplement (SIGH-ADS), the Mania Rating Scale and the Pittsburgh Sleep Quality Index to assess symptoms weekly. Remission was defined as having SIGH-ADS score of ≤8.

Patients in both treatment groups had moderate depression and no hypomanic or manic symptoms at baseline. Patients treated with bright white light, compared with those in the placebo light group, had a significantly higher remission rate (68.2 percent vs 22.2 percent; adjusted odds ratio, 12.6) at weeks 4‒6 and significantly lower depression scores (9.2 vs 14.9; adjusted β, ‒5.91) at the endpoint visit.

There were no mood polarity switches seen among patients. Both groups had improved sleep quality, which did not show significant difference between them.

“Patients with bipolar disorder have recurrent major depression, residual mood symptoms and limited treatment options,” the investigators said.

In one study, depression during pregnancy was improved significantly more with bright white light treatment for 5 weeks than with placebo dim red light, providing evidence that light therapy, a simple, cost-effective antidepressant modality with minimal side effects for the mother and no known risk for the unborn child, may be a beneficial nonpharmacologic strategy in this situation. [J Clin Psychiatry 2011;72:986-993]

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Most Read Articles
Roshini Claire Anthony, 2 days ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 5 days ago
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
3 days ago
The simple Atrial fibrillation (AF) Better Care (ABC) pathway holistically updates the integrated care for AF patients and helps reduce the risk of adverse outcomes such as all-cause mortality, stroke/major bleeding/cardiovascular death and hospitalization, according to a study.
14 hours ago
Type 1 diabetes impairs cognitive functioning in children, and this effect is exacerbated by extreme glycaemic levels, according to a recent meta-analysis.