Most Read Articles
Pearl Toh, 10 Jan 2018
A study finds no evidence that using pharmaceutical aids alone for smoking cessation helps improve the chances of successful quitting despite promising results in previous randomized trials and routine prescription of such drugs to help quit smoking.
Elvira Manzano, 16 Jan 2018
Cancer patients at risk for recurrent venous thromboembolism (VTE) are less likely to experience recurrence with rivaroxaban compared with dalteparin, the Select-D trial has shown, ushering in a new standard of care (SoC) for cancer-related VTE.
3 days ago
Rates of immunization particularly in a primary care setting can be improved by constant patient reminders and recall systems, a recent study has found.
4 days ago
It appears that urgent repeat endoscopic retrograde cholangiopancreatography (ERCP) predicts failure of plastic stent treatment for biliary strictures (BS) following liver transplant, according to a study.

Brentuximab vedotin shows superiority to standard therapy for cutaneous T cell lymphoma

Dr. Joseph Delano Fule Robles
21 Dec 2016

Findings from a phase III trial show that the anti-CD30 antibody-drug conjugate, brentuximab vedotin (BV), is superior to methotrexate or bexarotene in the efficacy endpoint of overall response rate (ORR) lasting ≥4 months in the treatment of cutaneous T cell lymphoma (CTCL).

Results of ALCANZA, the first trial testing a new agent against standard therapy in CTCL, were presented recently at the American Society of Hematology (ASH) 58th Annual Meeting. [ASH 2016, abstract 182]

The authors reported that at a median follow-up of 17.5 months, the primary endpoint of ORR lasting ≥ 4 months was achieved in 56 percent of patients treated with BV vs 13 percent of those treated with standard therapy (methotrexate or bexarotene) (p<0.0001). ORR (67 vs 20 percent) and complete response (CR) rates (16 vs 2 percent) were also significantly higher in the BV vs standard therapy group (p<0.01 for both).

BV also fared better than standard therapy in terms of the secondary endpoints of progression-free survival (PFS) (median,16.7 vs 3.5 months; hazard ratio [HR], 0.270; p<0.0001) and symptom reduction (measured by Skindex-29) (-27.96 vs -8.62; p<0.0001).

“These compelling results have potential practice-changing implications,” said investigator Dr Youn Kim from the Stanford University School of Medicine, Stanford, California, US.

In the study, 128 CTCL patients expressing CD30 who had received ≥1 prior systemic or radiotherapy were randomized receive either BV 1.8 mg/kg intravenously once every 3 weeks, or standard therapy with methotrexate (5–50 mg) orally once weekly or bexarotene (300 mg/m2) orally once daily.

BV, is an antibody-drug conjugate targeting CD30. The anti-CD30 antibody is coupled with a cytotoxic agent, monomethyl auristatin E, via a peptide linker and is released to cause cell death by induced growth arrest and apoptosis when the complex comes in contact with CD30-containing tumour cells. [Blood 2014;124:3197-3200]

Serious adverse effects were seen in 29 percent of patients in each arm. The rate of peripheral neuropathy of any grade was higher in patients receiving BV vs methotrexate or bexarotene (67 vs 6 percent). However, 82 percent of patients who developed peripheral neuropathy had improvement or resolution of symptoms at the last follow-up. Discontinuation of treatment due to adverse effects was more common in the BV vs standard therapy group (24 vs 8 percent).

CTCLs are a heterogeneous group of disease composed of a clonal population of skin-homing malignant T or natural killer (NK) cells. Each entity has unique prognostic and predictive characteristics. CTCLs are generally considered incurable with main goals of therapy being control of symptoms, cosmesis and extending survival. [J Clin Pathol 2015;68:1003-1010]

The multicentre, open-label ALCANZA trial is the first study that demonstrated superior outcomes with a drug compared with standard therapy for CTCL. 

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Pearl Toh, 10 Jan 2018
A study finds no evidence that using pharmaceutical aids alone for smoking cessation helps improve the chances of successful quitting despite promising results in previous randomized trials and routine prescription of such drugs to help quit smoking.
Elvira Manzano, 16 Jan 2018
Cancer patients at risk for recurrent venous thromboembolism (VTE) are less likely to experience recurrence with rivaroxaban compared with dalteparin, the Select-D trial has shown, ushering in a new standard of care (SoC) for cancer-related VTE.
3 days ago
Rates of immunization particularly in a primary care setting can be improved by constant patient reminders and recall systems, a recent study has found.
4 days ago
It appears that urgent repeat endoscopic retrograde cholangiopancreatography (ERCP) predicts failure of plastic stent treatment for biliary strictures (BS) following liver transplant, according to a study.