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Breast cancer a smoking-related disease

04 Feb 2019

The increased risk of breast cancer associated with smoking is similar across racial/ethnic groups and by oestrogen (ER) and progesterone (PR) receptor status, a study has found. This suggests that breast cancer should be considered as a smoking-related disease.

Researchers looked at 67,313 women aged 45–75 years who were enrolled in the Multiethnic Cohort (MEC) study, identifying breast cancer cases and tumour receptor status via linkage to the Hawaii and California Surveillance, Epidemiology and End Results Program cancer registries.

During a mean follow-up of 16.7 years, 4,230 women developed invasive breast cancer. Cox regression analysis showed that the risk of breast cancer overall was higher in parous ever smokers who had smoked >5 years prior to their first live childbirth than in parous never smokers (hazard ratio [HR], 1.31; 95 percent CI, 1.14–1.51).

Moreover, the risk increase was pronounced for African Americans (HR, 1.51; 1.05–2.16), for Native Hawaiians (HR, 1.66; 1.10–2.50), for whites (HR, 1.42; 1.13–1.78), for ER-positive tumours (HR, 1.37; 1.17–1.61) and PR-positive tumours (HR, 1.33; 1.11–1.59).

The estimates showed that the risk of incident breast cancer did not differ by racial/ethnic groups (p=0.15) or tumour receptor status (p=0.60 by ER status; p=0.95 by PR status).

The MEC data indicate that breast cancer should be considered as a smoking-related cancer, researchers said.

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Most Read Articles
Natalia Reoutova, Yesterday

A recent study involving 99 patients in Hong Kong demonstrated that arsenic trioxide (As2O3), used as part of induction and maintenance treatment for newly diagnosed acute promyelocytic leukaemia (APL), is safe and highly effective, achieving 100 percent complete response (CR), 3-year leukaemia-free survival (LFS) and 3-year overall survival (OS) rates. 

Natalia Reoutova, 16 Aug 2019
A recently published study involving 4,517 individuals confirmed the role of BRCA2 mutations in genetic predisposition to oesophageal squamous cell carcinoma (OSCC) among Chinese.