Most Read Articles
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Brachial-cuff excess pressure tied to carotid intima–media thickness

06 Apr 2020

Cuff-based excess pressure (XSP) is modestly associated with carotid intima–media thickness independent of conventional risk factors, reveals a recent study.

Cuff oscillometry was used to measure the reservoir pressure (RP) and XSP derived from brachial volumetric waveforms in 1,691 midlife adults from the CheckPoint study, a population-based cross-sectional study nested in the Longitudinal Study of Australian Children.

The authors measured carotid IMT (n=1,447) and carotid–femoral pulse wave velocity (PWV; n=1,632) as preclinical phenotypes of cardiovascular risk. Confounders included conventional risk factors associated with both exposures and outcomes or deemed as psychologically significant.

After adjusting for age, sex, body mass index, heart rate, smoking, diabetes, high-density lipoprotein cholesterol and mean arterial pressure, a weak association existed between XSP and carotid (β, 0.76 μm, 95 percent confidence interval [CI], 0.25–1.26; partial R2, 0.8 percent).

In similarly adjusted models, both RP and XSP did not correlate with PWV (RP: β, –0.47 cm/s, 95 percent CI, –1.15 to 0.20; partial R2, 0.2 percent; XSP: β, 0.04 cm/s, 95 percent CI, −0.59 to 0.67; partial R2, 0.01 percent).

More research is needed to understand the clinical significance of reservoir pressure parameters, according to the authors.

“Reservoir pressure parameters measured using tonometry predict cardiovascular events beyond conventional risk factors,” the authors noted, noting that their widespread use is hindered by the operator dependency of tonometry.

“An operator-independent cuff-based device can reasonably estimate the intra-aortic RP and XSP from brachial volumetric waveforms,” they added.

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Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
Elvira Manzano, 13 Apr 2020
A gout drug that’s been around for years reduced the risk of ischaemic cardiovascular (CV) events when given at a low dose in patients who had myocardial infarction (MI) and was cost-effective, an analysis of the COLCOT* trial has shown.
27 May 2020
Glycated haemoglobin (HbA1c) levels appear to be an independent predictor of coronary artery disease in patients with ST-elevation myocardial infarction, a new study has found.