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01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.

BP variability at midlife tied to long-term all-cause, CHD, stroke mortality

11 Sep 2020

Blood pressure variability (BPV) over 5 years in a cohort of tenured male workers appears to increase the risk of 18-year all-cause, coronary heart disease (CHD), and stroke mortality, suggests a recent study.

“Elevated BP is associated with cardiovascular mortality,” the authors said. “BPV is also associated with cardiovascular mortality, [but] most studies evaluated hypertensive patients with a relatively short follow-up.”

This study included 10,059 men, aged 40–65 years, tenured civil servants, and municipal employees in Israel, among whom 9,398 who were examined in 1963, 1965, and 1968 had assessment of diabetic and coronary morbidity status and systolic (S)BP levels. Participants underwent clinical and biochemical assessments and had their BP measured in the recumbent position on the right arm.

The authors carried out analysis for standard deviation (SD)-SBP across study visits. They also calculated hazard ratios (HRs) for 18-year all-cause mortality, CHD, and stroke mortality associated with quintile of SD-SBP, with the lowest quintile serving as a reference.

In multivariate analysis, SD-SBP significantly correlated with all-cause, CHD, and stroke mortality. Age- and SBP-adjusted HRs of all-cause mortality for quintile 2–5 were as follows: 1.02 (95 percent confidence interval [CI], 0.90–1.17), 1.06 (95 percent CI, 0.94–1.20), 1.20 (95 percent CI, 1.06–1.35), and 1.36 (95 percent CI, 1.21–1.53), respectively.

Likewise, age-adjusted risk for CHD and stroke mortality elevated with increasing SD-SBP. Further adjustment for smoking, body mass index, diabetes mellitus, and CHD yielded similar results, according to the authors.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.