Most Read Articles
Jairia Dela Cruz, 3 days ago
Metabolic and bariatric surgery (MBS) leads to large and sustained reductions in, and even reversal of, multiple risk factors for future joint disease in adolescents with severe obesity and musculoskeletal pain, according to data from the Teen Longitudinal Assessment of Bariatric Surgery study.
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Pearl Toh, 6 days ago
Obeticholic acid significantly improves fibrosis and disease activity in patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease currently with no approved therapy, according to an interim analysis of the landmark REGENERATE* study.

BP elevations during third trimester of pregnancy a red flag for future hypertension

20 Nov 2019

Pregnant women with elevated blood pressure (BP) levels below the diagnostic criteria of hypertensive disorders of pregnancy (HDP) at 28 and 34 weeks of gestation are at high risk of developing stage 1 hypertension 5 years later, a study has found.

The study included 329 women from the ROLO study (Randomized cOntrol trial of LOw glycaemic index diet to prevent the recurrence of macrosomia). Researchers measured maternal BP at several timepoints: 13, 28 and 34 weeks’ gestation, day 1 postpartum, and at the 5‐year follow‐up.

Systolic (SBP) and diastolic BP (DBP) were categorized as normal (SBP <120 and DBP <80 mm Hg), elevated (SBP 120–129 and DBP <80 mm Hg), stage 1 (SBP 130–139 or DBP 8–89 mm Hg) or stage 2 hypertension (SBP ≥140 or DBP ≥90 mm Hg).

Results showed significant positive associations between SBP, DBP and mean arterial pressure (MAP) in pregnancy and the same parameters at the 5‐year follow‐up. Women with elevated BP in pregnancy were three times (95 percent confidence interval [CI], 1.05–8.52; p=0.04) as likely as those who had normal BP to have stage 2 hypertension at 5-year follow‐up.

Moreover, elevated BP at 28 and 34 weeks’ gestation was associated with a more than twofold higher odds of having stage 1 hypertension at follow-up (odds ratios, 2.68, 95 percent CI, 1.36–5.27 and 2.45, 95 percent CI, 1.22–4.95, respectively; p=0.004 and p=0.012).

Each 1-mm Hg increase in SBP and DBP at 34 weeks of gestation increased the odds of having stages 1 and 2 hypertension 5 years later by 4 percent and 5 percent, respectively.

In light of the findings, the researchers recommend that pregnant women with raised BP below the diagnostic criteria of HDP be flagged for follow‐up postpartum, which could potentially facilitate more timely nonpharmacological interventions and, in turn, benefit overall lifetime health.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Jairia Dela Cruz, 3 days ago
Metabolic and bariatric surgery (MBS) leads to large and sustained reductions in, and even reversal of, multiple risk factors for future joint disease in adolescents with severe obesity and musculoskeletal pain, according to data from the Teen Longitudinal Assessment of Bariatric Surgery study.
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Pearl Toh, 6 days ago
Obeticholic acid significantly improves fibrosis and disease activity in patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease currently with no approved therapy, according to an interim analysis of the landmark REGENERATE* study.