Most Read Articles
18 Apr 2018
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 5 days ago
Infants delivered via caesarean section may be at increased risk of developing acute lymphoblastic leukaemia, according to a US study. Altered microbiota colonization is a possible explanation for this risk, although clear biological mechanisms have yet to be established.
5 days ago
Treatment with danegaptide does not improve myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention, according to the results of a phase II study.
4 days ago
Men with high levels of exposure to diesel exhaust are at greater risk of developing amyotrophic lateral sclerosis (AML), as shown in a recent study. This is not true for women.

BP-BES better than DP-DES at reducing adverse events, stent thrombosis

14 Nov 2017

BP-BES (biodegradable polymer biolimus-eluting stents) leads to lower rates of target lesion revascularization (TLR), major adverse cardiac events (MACE) and stent thrombosis (ST) at 5 years compared with DP-DES (durable polymer drug-eluting stents), according to a new meta-analysis.

After applying the selection criteria, the meta-analysis was performed on five studies corresponding to 4,687 patients. The studies were retrieved from the databases of the Cochrane Library, Embase and PubMed.

Pooled data from four trials showed that BP-BES significantly reduced the risk of MACE compared to first-generation DP-DES (odds ratio [OR], 0.80; 95 percent CI, 0.68 to 0.95; p=0.01). In contrast, the risk of MACE was not significantly different between BP-BES and second-generation DP-DES (OR, 0.96; 0.68 to 1.37p =0.38).

Overall, however, BP-BES significantly reduced the risk of MACE compared with DP-DES (OR, 0.83; 0.71 to 0.97; p=0.02). Similarly, BP-BES significantly reduced the risk of TLR compared to first-generation (OR, 0.73; 0.58 to 0.92; p=0.008) but not second-generation (OR, 1.34; 0.63 to 2.83; p=0.44) DP-DES. Overall, BP-BES was better than DP-DES in reducing the risk of TLR (OR, 0.77; 0.62 to 0.96; p=0.02).

BP-BES was again superior to first-generation (OR, 0.57; 0.39 to 0.82; p=0.002) but not second-generation (OR, 87; 0.35 to 2.16; p=0.76) DP-DES in reducing the risk of ST. Overall, the risk of ST was significantly lower with BP-BES than DP-DES (OR, 0.60; 0.43 to 0.84; p=0.003).

On the other hand, BP-BES showed no clear advantage over DP-DES in reducing the risk of death (OR, 0.89; 0.72 to 1.11; p=0.30), myocardial infarctions (OR, 0.88; 0.70 to 1.10; p=0.27) and target vessel revascularization (OR, 0.89; 0.73 to 1.08; p=0.23).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
18 Apr 2018
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 5 days ago
Infants delivered via caesarean section may be at increased risk of developing acute lymphoblastic leukaemia, according to a US study. Altered microbiota colonization is a possible explanation for this risk, although clear biological mechanisms have yet to be established.
5 days ago
Treatment with danegaptide does not improve myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention, according to the results of a phase II study.
4 days ago
Men with high levels of exposure to diesel exhaust are at greater risk of developing amyotrophic lateral sclerosis (AML), as shown in a recent study. This is not true for women.