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01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 4 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
4 days ago
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Body mass index matters little in success of intrauterine insemination

22 Nov 2020

Women who are overweight or obese do not necessarily have lower chances of a successful birth following infertility treatments, including intrauterine insemination, relative to women with normal weight, a study has found.

The analysis was based on 3,217 IUI treatment cycles in 1,306 patients (mean age, 32 years; mean body mass index [BMI], 27.5 kg/m2). Forty-seven percent of the cycles were in normal weight women, 24.1 percent in overweight women, and 28.3 percent in obese women (mean BMI, 37.3 kg/m2). The total motile sperm in the inseminate was similar across the BMI groups.

Most treatments were indicated for unexplained infertility (30 percent), while others were for male factor infertility (19 percent) or anovulation (16 percent). Anovulation was common in the obese group (25 percent). Oral ovulation induction was used in the majority of cycles (61 percent), unmedicated IUI in 14 percent, and injectable ovulation induction in 23 percent.

Live birth rates were similar between normal weight and obese women (10 percent vs 11 percent; adjusted odds ratio [aOR], 1.02, 95 percent confidence interval [CI], 0.76–1.37). When analysing BMI as a continuous variable, each unit increase in BMI had a null effect on birth success (aOR, 1.00, 95 percent CI, 0.984–1.019; p=0.906). There also was no difference in rates of clinical pregnancy, multiple gestation, or multiple delivery.

However, a BMI ≥30 kg/m2 was associated with a higher likelihood of biochemical pregnancy compared with a BMI in the normal range (aOR, 2.37, 95 percent CI, 1.33–4.25). Neither miscarriage nor an ectopic pregnancy was more likely to occur in the obese group.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 4 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
4 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.