Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
Audrey Abella, 16 Sep 2020
The final results of EVAPORATE* reinforce the plaque-regressing potential of icosapent ethyl (IPE) in patients on statins for elevated triglycerides.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.

BNP predicts adverse events in apical hypertrophic cardiomyopathy

26 Aug 2020
There are many heart diseases that are relatively unheard of despite the stark prevalence of heart diseases in our region.

Elevated levels of B-type natriuretic peptide (BNP) may help predict the incidence of adverse events and related outcomes in patients with apical hypertrophic cardiomyopathy (HCM), a recent study has found.

The study included 144 patients with apical HCM, in whom the median BNP concentration was 188.5 pg/mL. Over 9.5 years of follow-up, 23.6 percent (n=34) of the cohort developed HCM-related adverse outcomes, such as sudden death, stroke-related death, non-fatal stroke, and heart failure hospitalization, among others.

The researchers saw that BNP levels at enrolment were significantly higher in patients who did vs did not develop the combined HCM endpoints (334.4 vs 133.4 pg/mL; p<0.001).

Receiver operating characteristic (ROC) curve analysis showed that at an optimal cutoff of ≥226.0 pg/mL, BNP was sufficiently indicative of the study endpoint, with an area under the ROC curve of 0.756, and sensitivity and specificity values of 73.5 percent and 68.2 percent, respectively.

Twenty-five patients with high BNP developed the combined endpoint over a median of 8.9 years, yielding a rate of 41.7 percent. Of these, there was one case of sudden death, four stroke-related deaths, seven non-fatal strokes, and 10 heart failure hospitalizations. In contrast, only nine episodes (10.7 percent) were reported in the low-BNP participants, over a longer follow-up period of 9.8 years.

Multivariable analysis confirmed that the risk for combined HCM-related adverse events was significantly elevated in patients with BNP >226.0 pg/mL (adjusted hazard ratio, 4.46, 95 percent confidence interval, 2.07–9.61; p<0.001).

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Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
Audrey Abella, 16 Sep 2020
The final results of EVAPORATE* reinforce the plaque-regressing potential of icosapent ethyl (IPE) in patients on statins for elevated triglycerides.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.