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BMI inversely related to stroke risk in T2D patients

19 Jan 2020
BMI and WHR are a predictor of breast cancer subtypes in Chinese women with higher BMI not being a protective factor.

Body mass index (BMI) is inversely associated with the risk of total, ischaemic and haemorrhagic stroke among patients with type 2 diabetes (T2D), suggests a recent study.

A total of 8,918 incident stroke events occurred among 67,086 T2D patients during a mean follow-up of 3.74 years. Across different categories of BMI at baseline (18.5–24.9 [reference group], 25.0–29.9, 30.0–34.9, 35.0–39.9 and ≥40 kg/m2), multivariable-adjusted hazard ratios were 1.00, 0.92, 0.85, 0.74 and 0.63 (p-trend<0.001) for total stroke; 1.00, 0.93, 0.88, 0.77 and 0.65 (p-trend<0.001) for ischaemic stroke; and 1.00, 0.79, 0.50, 0.50 and 0.41 (p-trend<0.001) for haemorrhagic stroke, respectively.

The graded inverse association between BMI and stroke risk did not change when an updated mean BMI value was used. In addition, the linear association was consistent among patients of different subgroups.

“Further sensitivity analysis excluding patients who were diagnosed stroke within 6 months after first diagnosis of T2D or including nonsmokers only also confirmed our findings,” the authors said.

“More clinical and molecular insights are still needed in explaining these findings,” they added.

This retrospective cohort study that examined the relationship between BMI and stroke risk in T2D patients extracted demographic, anthropometric, laboratory and medication information from the National Patient-Centered Clinical Research Network common data model. Incident stroke, including both ischaemic and haemorrhagic, were defined.

“Very few studies focused on the association between BMI and stroke risk among patients with diabetes,” the authors noted.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 4 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.