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BMI inversely related to stroke risk in T2D patients

19 Jan 2020
BMI and WHR are a predictor of breast cancer subtypes in Chinese women with higher BMI not being a protective factor.

Body mass index (BMI) is inversely associated with the risk of total, ischaemic and haemorrhagic stroke among patients with type 2 diabetes (T2D), suggests a recent study.

A total of 8,918 incident stroke events occurred among 67,086 T2D patients during a mean follow-up of 3.74 years. Across different categories of BMI at baseline (18.5–24.9 [reference group], 25.0–29.9, 30.0–34.9, 35.0–39.9 and ≥40 kg/m2), multivariable-adjusted hazard ratios were 1.00, 0.92, 0.85, 0.74 and 0.63 (p-trend<0.001) for total stroke; 1.00, 0.93, 0.88, 0.77 and 0.65 (p-trend<0.001) for ischaemic stroke; and 1.00, 0.79, 0.50, 0.50 and 0.41 (p-trend<0.001) for haemorrhagic stroke, respectively.

The graded inverse association between BMI and stroke risk did not change when an updated mean BMI value was used. In addition, the linear association was consistent among patients of different subgroups.

“Further sensitivity analysis excluding patients who were diagnosed stroke within 6 months after first diagnosis of T2D or including nonsmokers only also confirmed our findings,” the authors said.

“More clinical and molecular insights are still needed in explaining these findings,” they added.

This retrospective cohort study that examined the relationship between BMI and stroke risk in T2D patients extracted demographic, anthropometric, laboratory and medication information from the National Patient-Centered Clinical Research Network common data model. Incident stroke, including both ischaemic and haemorrhagic, were defined.

“Very few studies focused on the association between BMI and stroke risk among patients with diabetes,” the authors noted.

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Most Read Articles
Pearl Toh, 4 days ago
Every-two-month injections of the long-acting cabotegravir + rilpivirine were noninferior to once-monthly injections for virologic suppression at 48 weeks in people living with HIV*, according to the ATLAS-2M** study presented at CROI 2020 — thus providing a potential option with more convenient dosing.
Stephen Padilla, 19 Mar 2020
The assumption that children are less vulnerable to the coronavirus disease 2019 (COVID-19) compared to adults is not quite true and may even be dangerous, suggests a recent study.
22 Mar 2020
Sustained use of lopinavir-combined regimen appears to confer benefits among patients with the novel coronavirus disease (COVID-19), with improvement possibly indicated by increasing eosinophils, suggests a recent study.
24 Mar 2020
COVID-19 is a novel disease, with no existing immunity. The virus can be transmitted from person to person, quickly and exponentially. Here’s what we can do to slow down the spread, if not contain the outbreak.