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BMI inversely related to stroke risk in T2D patients

19 Jan 2020
BMI and WHR are a predictor of breast cancer subtypes in Chinese women with higher BMI not being a protective factor.

Body mass index (BMI) is inversely associated with the risk of total, ischaemic and haemorrhagic stroke among patients with type 2 diabetes (T2D), suggests a recent study.

A total of 8,918 incident stroke events occurred among 67,086 T2D patients during a mean follow-up of 3.74 years. Across different categories of BMI at baseline (18.5–24.9 [reference group], 25.0–29.9, 30.0–34.9, 35.0–39.9 and ≥40 kg/m2), multivariable-adjusted hazard ratios were 1.00, 0.92, 0.85, 0.74 and 0.63 (p-trend<0.001) for total stroke; 1.00, 0.93, 0.88, 0.77 and 0.65 (p-trend<0.001) for ischaemic stroke; and 1.00, 0.79, 0.50, 0.50 and 0.41 (p-trend<0.001) for haemorrhagic stroke, respectively.

The graded inverse association between BMI and stroke risk did not change when an updated mean BMI value was used. In addition, the linear association was consistent among patients of different subgroups.

“Further sensitivity analysis excluding patients who were diagnosed stroke within 6 months after first diagnosis of T2D or including nonsmokers only also confirmed our findings,” the authors said.

“More clinical and molecular insights are still needed in explaining these findings,” they added.

This retrospective cohort study that examined the relationship between BMI and stroke risk in T2D patients extracted demographic, anthropometric, laboratory and medication information from the National Patient-Centered Clinical Research Network common data model. Incident stroke, including both ischaemic and haemorrhagic, were defined.

“Very few studies focused on the association between BMI and stroke risk among patients with diabetes,” the authors noted.

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Most Read Articles
Elaine Soliven, 4 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

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Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 3 days ago
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