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Roshini Claire Anthony, 23 hours ago

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

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BMI a causal factor for osteoarthritis at weight-bearing joints

20 Oct 2019

High body mass index (BMI) is causally associated with the risk of osteoarthritis (OA) at the knee and hip but not at the hand, a study has found.

Researchers used data from the UK Biobank study involving 384,838 unrelated participants. They performed Mendelian randomization (MR) analyses to test for causality for BMI, bone mineral density (BMD), serum high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglyceride levels, type 2 diabetes, systolic blood pressure (SBP), and C-reactive protein (CRP) levels.

A total of 48,431 participants had all-site OA, whereas 19,727 had knee OA, 11,875 had hip OA and 2,330 had hand OA. On MR analyses, genetically determined BMI had a strong causal association with all-site (odds ratio [OR] per standard deviation [SD] increase, 1.57, 95 percent CI, 1.44–1.71), knee (OR, 1.76, 1.56–1.99) and hip OA (OR, 1.52, 1.31–1.78) but not hand OA.

A similar pattern of association was observed between genetically determined femoral neck BMD and all-site (OR, 1.14, 1.06–1.22), knee (OR, 1.18, 1.05–1.32) and hip OA (OR, 1.22, 1.09–1.35) but not hand OA.

Low SBP was also causally associated with all-site (OR, 0.64, 0.54–0.77), knee (OR, 0.66, 0.57–0.77) and hip OA (OR, 0.63, 0.48–0.82). There was no evidence of causality for the other tested metabolic factors or CRP level.

The present data may be used for future investigations in OA, including the prevention or therapeutic strategies for the different OA locations, the researchers said.

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Most Read Articles
Roshini Claire Anthony, 23 hours ago

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
6 days ago
Men who undergo flexible cystoscopy, particularly with a longer dwell time, may benefit from intraurethral lidocaine as it provides significant pain reduction, suggest the results of a meta-analysis. Evidence is lacking for other tested interventions.
Tristan Manalac, 2 days ago
Users of electronic nicotine delivery systems are likely to have received a diagnosis of clinical depression in the past, according to a recent study.