Most Read Articles
2 days ago
Dairy consumption during adolescence or early adulthood does not appear to be associated with the overall risk of breast cancer, although results vary by hormone receptor status of tumours, a study has shown. Specifically, dairy intake is linked to higher ER–/PR– and lower ER+/PR+ cancer risk.
Roshini Claire Anthony, 5 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

3 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
4 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

Bmi-1 overexpression tied to distant metastasis, poor survival in NSCLC

22 Jul 2017

Overexpression of B-cell-specific Moloney leukaemia virus insertion site 1 (Bmi-1) is associated with poor overall survival (OS), distant metastasis and tumour size in nonsmall cell lung cancer (NSCLC), according to a new meta-analysis.

Pooled data from 14 studies (n=1,323) showed that Bmi-1 overexpression was significantly associated with tumour size (n=7; odds ratio [OR], 1.79; 95 percent CI, 1.19 to 2.71; p=0.005), poor differentiation (n=7; OR, 1.61; 1.11 to 2.33; p=0.011) and distant metastasis (n=4; OR, 4.69; 1.52 to 14.41; p=0.007).

Similarly, pooled data from eight studies (n=913) showed that Bmi-1 overexpression was significantly associated with poor survival in NSCLC patients (hazard ratio [HR], 1.62; 1.14 to 2.3; p<0.001).

In contrast, Bmi-1 expression showed no significant associations with age (OR, 1.13; 0.86 to 1.49; p=0.372), tumour/node/metastasis staging (OR, 0.91; 0.68 to 1.22; p=0.513), lymph node metastasis (OR, 1.25; 0.71 to 2.22; p=0.434), histology (OR, 1.07; 0.73 to 1.57; p=0.722) and smoking (OR, 1.2; 0.78 to 1.86; p=0.402).

The meta-analysis involved studies that investigated the relationship of Bmi-1 expression and clinical factors and overall survival in histologically confirmed NSCLC patients. Studies that reported HRs and ORs were included, while those that were case studies or animal studies were excluded. The databases of PubMed, Web of Science and Embase were accessed.

Begg test and Egger test were both employed to evaluate the risk of bias of the selected studies. None of the studies showed publication bias.

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Most Read Articles
2 days ago
Dairy consumption during adolescence or early adulthood does not appear to be associated with the overall risk of breast cancer, although results vary by hormone receptor status of tumours, a study has shown. Specifically, dairy intake is linked to higher ER–/PR– and lower ER+/PR+ cancer risk.
Roshini Claire Anthony, 5 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

3 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
4 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.