Most Read Articles
Roshini Claire Anthony, 4 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
2 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
3 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

BMI, fat free mass, irisin levels drop after high altitude climbing

04 Aug 2017
Viagra may be useful in HAPE prevention and treatment, but not for AMS or HACE.

Body mass, body mass index (BMI), irisin, 25-hydroxyvitamin D (25(OH)D) levels and fat free mass decrease significantly after hypobaric hypoxia from high-altitude climbing, a new study shows.

On the other hand, hypobaric hypoxia increases myoglobin, interleukin (IL)-6, osteoprotegerin (OPG) and high-sensitivity C-reactive protein (hsCRP) levels.

A total of eight males (mean age 27±2.8 years) who underwent a 2-week climbing expedition in the Alps were subjected to body composition measurements. Concentrations of hsCRP, myoglobin, irisin, 25(OH)D, OPG and other biomarkers were measured from collected blood samples.

Body mass (72.3±6.05 vs 70.7±5.18 kg), BMI (22.7±1.27 vs 22.2±0.83 kg/m2) and fat-free mass (84.2±2.36 vs 84.1±2.78 percent) decreased significantly from baseline following 2 weeks of hypobaric hypoxia (p<0.05 for all). Similarly, levels of 25(OH)D and irisin decreased significantly from baseline (p<0.05 for both).

On the other hand, concentrations of OPG, IL-6, hsCRP and myoglobin significantly increased compared with baseline values (p<0.05 for all).

Lean body mass was significantly positively associated with irisin levels at baseline (p=0.0009) and after the expedition (p=0.0366). Similarly, hsCRP was positively associated with OPG (p=0.0465) and with the ratio between OPG and high sensitivity soluble receptor activator of NF-κB ligand (sRANKL; p=0.0102) after the expedition.

Significant positive correlations were also found between IL-6 and myostatin (p=0.028), irisin and 25(OH)D (p=0.0366), hsCRP concentrations and OPG/sRANKL ratio (p=0.0009), and myostatin levels and OPG/sRANKL ratio (p=0.0065).

According to the investigators, these results suggest that certain myokines may play a role in skeletal muscle regeneration and energy processes following hypobaric hypoxia exposure.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 4 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
2 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
3 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.