Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

Blue light more sensitive than white light cystoscopy for bladder cancer surveillance

23 Dec 2017

Office-based blue light flexible cystoscopy (BLFC) significantly improves detection of patients with recurrent bladder cancer and is safe when performed for surveillance compared white light flexible cystoscopy (WLFC), as shown in a recent study.

Additionally, performing blue light cystoscopy (BLC) in the operating room (OR) significantly boosts detection of carcinoma in situ (CIS), as well as identifies lesions missed with white light cystoscopy (WLC).

The phase III multicentre study compared BLFC with WLFC in the detection of bladder cancer recurrence during surveillance. A total of 304 nonmuscle invasive bladder cancer patients received intravesical hexaminolevulinate before WLFC and BLFC. Those found to have suspicious lesions were referred to the OR for repeat WLC and BLC. All suspected lesions were biopsied or resected, with specimens examined by an independent pathology consensus panel.

The primary endpoint was the proportion of patients with histologically confirmed malignancy detected only with BLFC. Additional endpoints included false positive rate, detection of CIS, and additional tumours detected only with BLC.

Following surveillance, 103 patients were referred to the OR. Of these patients, 63 had confirmed malignancy, including 26 with CIS. Recurrence was detected only with BLFC in 13 of 63 patients (20.6 percent; p<0.0001), and five of these patients had confirmed CIS.

From the OR examination, 26 of 63 patients (41 percent) had confirmed CIS, with nine cases (34.6 percent) detected only with BLC (p<0.0001). BLC identified additional malignant lesions in 29 patients (46 percent).

False positive rates were similar between WLC and BLC (9.1 percent). There were 12 adverse events reported during surveillance, but none of which were serious.

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Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.