Most Read Articles
Roshini Claire Anthony, 6 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

6 days ago
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.
6 days ago
Short sleep duration is associated with an increased risk of myocardial infarction (MI), according to prospective observational and Mendelian randomization (MR) analyses.
Tristan Manalac, 6 days ago
The addition of ezetimibe improves statin treatment in acute coronary syndrome (ACS) patients with dyslipidaemia and low eicosapentaenoic acid-to-arachidonic acid (EPA/AA) ratio, resulting in a lowered risk of cardiovascular events compared to monotherapy, according to a study presented at the recently concluded 2019 Congress of the European Society of Cardiology (ESC 2019) held in Paris, France.

Bloodstream infections common among epidermal necrolysis patients

23 Jul 2019
Despite sepsis being UK’s top avoidable disease, many hospitals still fail to administer intravenous antibiotics to patients within the hour, adding to the staggering death toll rates.

Bloodstream infections (BSIs) are common among patients with epidermal necrolysis (EN) and are mostly caused by Staphylococcus aureus and Pseudomonas aeruginosa, a recent study has found. Skin cultures may help predict such infections.

Researchers performed a retrospective, single-centre observational study of 98 patients (median age, 49.6 years; 56 percent female) who had acute-phase EN with body surface area (BSA) involvement 10 percent. Information about blood and skin cultures, as well as the time and severity of BSI were collected and included in the analysis.

Almost half (46.9 percent; n=46) experienced at least one BSI episode after a median of 7 days after admission. A total of 85 cases were reported, and the incidence rate was 33.3 BSIs per 1,000 days of hospitalization per patient. More than half (52.2 percent; n=24) of the BSI patients experienced septic shock, while 26 percent (n=12) died.

S. aureus and P. aeruginosa accounted for majority of the positive blood cultures, each detected in 36.9 percent of the samples. Almost a fourth (23.9 percent) of blood cultures were polymicrobial.

Similarly, S. aureus (38 percent) was the most common infectious agent during the first skin culture, while P. aeruginosa (79 percent) dominated the third skin cultures. In 71.1 percent of the cases, bacteria isolated from the skin cultures corresponded with the bacteria responsible for the BSI.

In terms of diagnostic performance, skin cultures of S. aureus had a sensitivity of 88.2 percent and a specificity of 60.7 percent. Cultures of P. aeruginosa, on the other hand, had corresponding values of 75.0 percent and 58.4 percent.

Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 6 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

6 days ago
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.
6 days ago
Short sleep duration is associated with an increased risk of myocardial infarction (MI), according to prospective observational and Mendelian randomization (MR) analyses.
Tristan Manalac, 6 days ago
The addition of ezetimibe improves statin treatment in acute coronary syndrome (ACS) patients with dyslipidaemia and low eicosapentaenoic acid-to-arachidonic acid (EPA/AA) ratio, resulting in a lowered risk of cardiovascular events compared to monotherapy, according to a study presented at the recently concluded 2019 Congress of the European Society of Cardiology (ESC 2019) held in Paris, France.