Most Read Articles
06 Sep 2019
Gastric dysplasia (GD), specifically high-grade lesions, appears to carry an elevated risk of progression to gastric adenocarcinoma (GAC), according to the results of a meta-analysis.
Roshini Claire Anthony, 4 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

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05 Sep 2019
Supplementation with vitamin D appears to help reduce the serum concentration of total and low-density lipoprotein cholesterol and triglyceride but not high-density lipoprotein cholesterol, suggesting its usefulness for mitigating the risk of cardiovascular disease in patients with hypercholesterolaemia, according to the results of a meta-analysis.

Bloodstream infections common among epidermal necrolysis patients

23 Jul 2019
Despite sepsis being UK’s top avoidable disease, many hospitals still fail to administer intravenous antibiotics to patients within the hour, adding to the staggering death toll rates.

Bloodstream infections (BSIs) are common among patients with epidermal necrolysis (EN) and are mostly caused by Staphylococcus aureus and Pseudomonas aeruginosa, a recent study has found. Skin cultures may help predict such infections.

Researchers performed a retrospective, single-centre observational study of 98 patients (median age, 49.6 years; 56 percent female) who had acute-phase EN with body surface area (BSA) involvement 10 percent. Information about blood and skin cultures, as well as the time and severity of BSI were collected and included in the analysis.

Almost half (46.9 percent; n=46) experienced at least one BSI episode after a median of 7 days after admission. A total of 85 cases were reported, and the incidence rate was 33.3 BSIs per 1,000 days of hospitalization per patient. More than half (52.2 percent; n=24) of the BSI patients experienced septic shock, while 26 percent (n=12) died.

S. aureus and P. aeruginosa accounted for majority of the positive blood cultures, each detected in 36.9 percent of the samples. Almost a fourth (23.9 percent) of blood cultures were polymicrobial.

Similarly, S. aureus (38 percent) was the most common infectious agent during the first skin culture, while P. aeruginosa (79 percent) dominated the third skin cultures. In 71.1 percent of the cases, bacteria isolated from the skin cultures corresponded with the bacteria responsible for the BSI.

In terms of diagnostic performance, skin cultures of S. aureus had a sensitivity of 88.2 percent and a specificity of 60.7 percent. Cultures of P. aeruginosa, on the other hand, had corresponding values of 75.0 percent and 58.4 percent.

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Most Read Articles
06 Sep 2019
Gastric dysplasia (GD), specifically high-grade lesions, appears to carry an elevated risk of progression to gastric adenocarcinoma (GAC), according to the results of a meta-analysis.
Roshini Claire Anthony, 4 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Stephen Padilla, 5 days ago
Implementation of the collaborative care in a rheumatoid arthritis (RA) clinic has led to improvements in nonbiologic disease-modifying antirheumatic drugs (nb-DMARDs) optimization, adherence to safety recommendations on nb-DMARD monitoring and detection of adverse drug events in RA patients, according to a Singapore study.
05 Sep 2019
Supplementation with vitamin D appears to help reduce the serum concentration of total and low-density lipoprotein cholesterol and triglyceride but not high-density lipoprotein cholesterol, suggesting its usefulness for mitigating the risk of cardiovascular disease in patients with hypercholesterolaemia, according to the results of a meta-analysis.