Most Read Articles
Roshini Claire Anthony, 6 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Prof. Vincent Wong, Prof. Ray Kim, Dr. Tan Poh Seng, 10 Sep 2019
Chronic hepatitis B (CHB) remains a major public health concern because of its worldwide distribution and potential adverse sequelae, including cirrhosis and hepatocellular carcinoma (HCC). At a recent symposium held during the GIHep Singapore 2019, Professor Vincent Wong from the Chinese University of Hong Kong and Professor Ray Kim from the Stanford University School of Medicine, Stanford, California, US, discussed antiviral treatments for CHB, with a focus on the novel agent tenofovir alafenamide (Vemlidy®). Dr Tan Poh Seng from the National University Hospital, Singapore, chaired the symposium.
11 Sep 2019
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.
Pearl Toh, 18 hours ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.

Bloodstream infections common among epidermal necrolysis patients

23 Jul 2019
Despite sepsis being UK’s top avoidable disease, many hospitals still fail to administer intravenous antibiotics to patients within the hour, adding to the staggering death toll rates.

Bloodstream infections (BSIs) are common among patients with epidermal necrolysis (EN) and are mostly caused by Staphylococcus aureus and Pseudomonas aeruginosa, a recent study has found. Skin cultures may help predict such infections.

Researchers performed a retrospective, single-centre observational study of 98 patients (median age, 49.6 years; 56 percent female) who had acute-phase EN with body surface area (BSA) involvement 10 percent. Information about blood and skin cultures, as well as the time and severity of BSI were collected and included in the analysis.

Almost half (46.9 percent; n=46) experienced at least one BSI episode after a median of 7 days after admission. A total of 85 cases were reported, and the incidence rate was 33.3 BSIs per 1,000 days of hospitalization per patient. More than half (52.2 percent; n=24) of the BSI patients experienced septic shock, while 26 percent (n=12) died.

S. aureus and P. aeruginosa accounted for majority of the positive blood cultures, each detected in 36.9 percent of the samples. Almost a fourth (23.9 percent) of blood cultures were polymicrobial.

Similarly, S. aureus (38 percent) was the most common infectious agent during the first skin culture, while P. aeruginosa (79 percent) dominated the third skin cultures. In 71.1 percent of the cases, bacteria isolated from the skin cultures corresponded with the bacteria responsible for the BSI.

In terms of diagnostic performance, skin cultures of S. aureus had a sensitivity of 88.2 percent and a specificity of 60.7 percent. Cultures of P. aeruginosa, on the other hand, had corresponding values of 75.0 percent and 58.4 percent.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Prof. Vincent Wong, Prof. Ray Kim, Dr. Tan Poh Seng, 10 Sep 2019
Chronic hepatitis B (CHB) remains a major public health concern because of its worldwide distribution and potential adverse sequelae, including cirrhosis and hepatocellular carcinoma (HCC). At a recent symposium held during the GIHep Singapore 2019, Professor Vincent Wong from the Chinese University of Hong Kong and Professor Ray Kim from the Stanford University School of Medicine, Stanford, California, US, discussed antiviral treatments for CHB, with a focus on the novel agent tenofovir alafenamide (Vemlidy®). Dr Tan Poh Seng from the National University Hospital, Singapore, chaired the symposium.
11 Sep 2019
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.
Pearl Toh, 18 hours ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.