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Blood type affects warfarin needs

13 Jul 2020
Deep vein thrombosis (DVT) or atrial fibrillation (AF) patients with a non-O blood type appear to require higher warfarin doses, a recent study has found.

Researchers conducted a retrospective analysis of 358 patients (56.42 percent female), of whom 270 had AF and 88 had DVT. In terms of blood type, 111 patients were of type A, 104 were of type B, 20 had type AB, and 123 had type O. Blood type groups were largely comparable in terms of age, sex, comorbidities, medications, and blood chemistry.

Notably, minor bleeding (p=0.224) occurred at similar rates in the A, B, AB, and O blood type groups, and the international normalized ratio values were likewise statistically comparable (p=0.765).

Despite these, warfarin requirements appeared to be different. Those in the type O group, for example, needed significantly lower doses than their type A counterparts (2.74±0.83 vs 3.19±0.97 mg; p<0.01). The same discrepancy was true when O type needs were compared to blood types B (3.32±0.97 mg; p<0.05) and AB (3.14±0.93; p<0.05).

On the other hand, the warfarin dose requirements of blood types A, B, and AB were comparable.

Adjusting for patient weight, the difference in doses between O and non-O groups remained significant, further verifying that blood type affects the use of warfarin for anticoagulation.

“The mechanisms by which patients in the O blood group had lower warfarin dose requirements have not been fully elucidated,” researchers said, adding that future studies are required to determine this pathway of action.

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Most Read Articles
29 Jul 2020
Adjunctive perampanel appears to be safe and effective for long-term treatment of patients with tonic‐clonic seizures, according to a posthoc analysis.
27 Apr 2020
Long-term use of brivaracetam as an adjunctive treatment is well tolerated and effective in patients with focal seizures or primary generalized seizures, as shown in a study.
01 Apr 2019
Perampanel is safe and effective for treating refractory focal seizures in both Asian and non‐Asian populations, a study has found.
Elvira Manzano, 20 Jun 2018
A higher proportion of patients with systemic lupus erythematosus (SLE) experienced improvements in joint and skin symptoms with baricitinib 4 mg once daily vs placebo in a phase II randomized, double-blind, global study.