Most Read Articles
13 Aug 2019
Individuals with obesity are at an elevated risk of developing infections, particularly that of the skin in both men and women, and those of the gastrointestinal and urinary tracts and sepsis in women only, according to a study.
5 days ago
An increase in intensive care unit (ICU) management and bacterial pneumonia development occurs in children with special risk medical conditions (SRMC), but a rise in the probability of death or need for mechanical ventilation remains inconsistent, suggests a recent study.
Pearl Toh, 30 Aug 2019
Oral amoxicillin–clavulanate effectively promotes resolution of nonsevere acute exacerbations in children with non-cystic fibrosis (CF) bronchiectasis, thus confirming the role of amoxicillin–clavulanate as first-line treatment for bronchiectasis, according to results from the three-arm BEST-1 study.

Blood stream infections common in ECMO patients

02 May 2019

Blood stream infections (BSIs) commonly occur in patients on extracorporeal membrane oxygenation (ECMO), a recent study has found.

The study included 145 patients on veno-venous (VV) ECMO and 123 on veno-arterial (VA) ECMO. A total of 26 patients developed BSIs, resulting in an overall prevalence rate of 9.7 percent. This was higher in those on VV vs VA ECMO (13.1 percent vs 5.7 percent).

Because patients spent 2,336 and 888 days on VV and VA ECMO respectively, the corresponding BSI incidence rates were 8 and 8 BSIs per 1,000 VV and VA ECMO days.

Patients who developed BSIs while on VV (median, 18 vs 9 days; p=0.0007) and VA (17 vs 6 days; p=0.02) ECMO spent significantly longer time attached to the machine than counterparts who did not have the infection. Moreover, VV ECMO patients with BSIs required more red blood cell transfusions (20 vs 13 units; p=0.04).

The most common infectious agents in VV ECMO patients were species belonging to the Candida taxon and gram-negative bacilli, such as Pseudomonas aeruginosa, Acinetobacter baumannii, Burkholderia cepacia and Enterobacter aerogenes.

In comparison, Aeromonas hydrophila, Aeromonas caviae, Klebsiella pneumoniae, A. baumannii and P. aeruginosa were the most frequently occurring infectants in VA ECMO patients.

Acute renal failure significantly increased the likelihood of BSI in VV ECMO patients (odds ratio [OR], 3.31; 95 percent CI, 1.21–9.01), while acute hepatic failure was a significant risk factor in VA ECMO patients (OR, 11.56; 2.31–57.91).

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Most Read Articles
13 Aug 2019
Individuals with obesity are at an elevated risk of developing infections, particularly that of the skin in both men and women, and those of the gastrointestinal and urinary tracts and sepsis in women only, according to a study.
5 days ago
An increase in intensive care unit (ICU) management and bacterial pneumonia development occurs in children with special risk medical conditions (SRMC), but a rise in the probability of death or need for mechanical ventilation remains inconsistent, suggests a recent study.
Pearl Toh, 30 Aug 2019
Oral amoxicillin–clavulanate effectively promotes resolution of nonsevere acute exacerbations in children with non-cystic fibrosis (CF) bronchiectasis, thus confirming the role of amoxicillin–clavulanate as first-line treatment for bronchiectasis, according to results from the three-arm BEST-1 study.