Most Read Articles
04 Oct 2020
Obesity does not appear to be strongly correlated with an increased risk for febrile neutropaenia during levofloxacin prophylaxis in patients with haematological malignancies receiving intermediate-risk myelosuppressive chemotherapy, suggests a study.
Roshini Claire Anthony, 25 Nov 2020

Initiation or switch to the single-tablet regimen of bictegravir/emtricitabine/tenofovir alafenamide (TAF) led to low HIV-1 RNA viral load in people living with HIV (PLHIV), according to the BICSTaR study presented at HIV Glasgow 2020.

09 Nov 2020
Use of corticosteroids appears to be an effective treatment for paediatric drug reaction with eosinophilia and systemic symptoms (DRESS), suggest the results of a recent study. In severe cases, corticosteroids used in conjunction with intravenous immunoglobulin result in fast clinical improvement.
Stephen Padilla, 10 Nov 2020
Patients with chronic obstructive pulmonary disease (COPD) seem to benefit from using chlorhexidine oral rinses twice daily as shown by the reduction in oral and sputum microbiota alpha diversity and by clinically significant improvements in COPD symptoms, according to a study presented at ID Week 2020.

Block-replace ATD regimen prevents Graves’ disease relapse better than titration regimen

03 Apr 2020

In patients with Graves’ disease (GD), the block-replace antithyroid drug (ATD) regimen leads to a lower relapse rate than the titration regimen, according to a study. Factors such as younger age, larger goiter size or thyroid volume, and the higher free triiodothyronine or free thyroxine levels in the diagnosing phase are tied to a higher risk of relapse.

Researchers conducted a systematic review of prospective or retrospective studies of newly diagnosed GD patients aged >16 years and treated with ATD. Follow-up was performed for at least 12 months after ATD withdrawal. The meta-analysis included 20 studies involving 3,242 patients, with GD recurring in 1,681 patients during follow-up, corresponding to an incidence rate of 51.9 percent.

Risk factors for relapse included younger age (weighted raw mean difference [RMD], −3.51, 95 percent confidence interval [CI], −5.74 to −1.29), larger thyroid volume (RMD, 4.38, 95 percent CI, 1.68–7.08), bigger goiter size (1.94 percent risk, 95 percent CI, 0.43–3.46), higher free triiodothyronine level (RMD, 5.09, 95 percent CI, 4.42–5.77), and higher free thyroxine level (RMD, 4.21, 95 percent CI, 0.54–7.89).

The block-replace ATD regimen, which consisted of a fixed high dose of an ATD with levothyroxine supplementation to maintain euthyroidism, was associated with a lower relapse rate compared with the titration regimen, which involved monotherapy with ATD and dose adjusted according to thyroid function tests (risk ratio, 0.64, 95 percent CI, 0.52–0.78).

The risk factors identified in the current meta-analysis should facilitate early definitive treatment with radioactive iodine or surgery to patients who are unlikely to achieve remission with ATDs only, the researchers said. Additional prospective cohort studies with different ATD regimens are needed to determine the optimum treatment for patients with GD.

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Most Read Articles
04 Oct 2020
Obesity does not appear to be strongly correlated with an increased risk for febrile neutropaenia during levofloxacin prophylaxis in patients with haematological malignancies receiving intermediate-risk myelosuppressive chemotherapy, suggests a study.
Roshini Claire Anthony, 25 Nov 2020

Initiation or switch to the single-tablet regimen of bictegravir/emtricitabine/tenofovir alafenamide (TAF) led to low HIV-1 RNA viral load in people living with HIV (PLHIV), according to the BICSTaR study presented at HIV Glasgow 2020.

09 Nov 2020
Use of corticosteroids appears to be an effective treatment for paediatric drug reaction with eosinophilia and systemic symptoms (DRESS), suggest the results of a recent study. In severe cases, corticosteroids used in conjunction with intravenous immunoglobulin result in fast clinical improvement.
Stephen Padilla, 10 Nov 2020
Patients with chronic obstructive pulmonary disease (COPD) seem to benefit from using chlorhexidine oral rinses twice daily as shown by the reduction in oral and sputum microbiota alpha diversity and by clinically significant improvements in COPD symptoms, according to a study presented at ID Week 2020.