Most Read Articles
4 days ago
Being overweight or obese in adolescence appears to increase the risk of papillary thyroid cancer in adulthood, a recent study has shown.
Yesterday
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 29 Mar 2020
While the 2019 coronavirus disease (COVID-19) is generally mild in children, infants appear to be particularly susceptible to severe and critical infections, a new study has found.
5 days ago
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).

Blinding, shorter duration help reduce placebo responses in systemic therapy trials in AD

17 Dec 2019
Why do placebos work?

In clinical trials of systemic therapy in atopic dermatitis (AD), the integration of double- and triple-blinding can lower placebo responses, according to the results of a systematic review and meta-analysis. Other means of achieving this include balancing of patient sex distribution, disallowing concomitant use of prescription topical therapy and having shorter study durations.

The investigators performed a systematic review and meta-analysis of randomized controlled trials examining the use of systemic therapy in AD published between 2007 and 2018. They searched the databases of Cochrane Library, Medline, Embase, Global Resource for Eczema Trials, Literature of the Latin American and Caribbean Health Sciences and Scopus.

Study selection and data extraction were carried out by two investigators. Multivariable mixed models were generated for the following: Cohen D of Eczema Area and Severity Index (EASI), SCORing Atopic Dermatitis (SCORAD), numeric rating scale (NRS)–itch and visual analogue scale (VAS)–itch, and Dermatology Life Quality Index (DLQI).

Sixty-four trials met the eligibility criteria. Higher placebo responses were associated with use of concomitant topical therapy prescriptions, study duration ≥3 months and fewer treatment arms for EASI, NRS- and VAS-itch, and DLQI.

For EASI, studies with a higher proportion of male patients, mild-to-moderate mean baseline EASI scores and no blinding had higher placebo responses. For NRS- and VRS-itch, the placebo response was increased in studies with higher proportion of male patients and moderate-to-severe mean itch scores at baseline.

“AD has a variable disease course and intermittent triggers, and responses to topical therapy vary, potentially affecting the magnitude of the placebo response in AD trials,” the investigators said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
4 days ago
Being overweight or obese in adolescence appears to increase the risk of papillary thyroid cancer in adulthood, a recent study has shown.
Yesterday
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 29 Mar 2020
While the 2019 coronavirus disease (COVID-19) is generally mild in children, infants appear to be particularly susceptible to severe and critical infections, a new study has found.
5 days ago
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).