Most Read Articles
01 Nov 2019
Women with hypertensive disorders of pregnancy, especially pre-eclampsia, are at heightened risk of developing cardiovascular disorder and chronic hypertension, with the risk becoming apparent soon after pregnancy, a study has found.
Roshini Claire Anthony, 29 May 2019

Gestational diabetes and abnormal glucose levels in pregnancy, as determined with an oral glucose challenge test (OGCT) at 24–28 weeks gestation, could signal a future risk of cardiovascular disease (CVD)*, according to a recent study.

07 Jul 2019
Plasma creatinine kinase activity, measure during early pregnancy, influences blood pressure during pregnancy and contributes to severe gestational hypertension diagnosed before 34 weeks of gestation, according to a recent study. There is no association between creatinine kinase and other hypertensive disorders during pregnancy.
Pank Jit Sin, 16 Oct 2019
While a diagnosis of cancer is often met with concern and devastation, the same is barely true for heart failure. However, the mortality rate for those suffering from heart failure is worse than some common cancers, such as prostate and breast cancers. 

Bleeding linked to increased cancer risk in atherosclerotic patients on antithrombotics

08 Oct 2019

Any gastrointestinal or genitourinary bleeding carries a 20–30-fold higher hazard for new cancer diagnosis in the respective organ systems in patients with atherosclerosis receiving antithrombotic drug treatment, as shown in a recent study.

The study used data from the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) trial and included 27,395 patients (mean age, 68 years; 21 percent) new cancers diagnosed in relation to gastrointestinal or genitourinary bleeding among patients enrolled in the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) trial.

During a mean follow-up of 23 months, any (major or minor) bleeding occurred in 2,678 patients (9.8 percent), among whom 257 (9.9 percent) were subsequently diagnosed with cancer.

Gastrointestinal bleeding was associated with an increased risk of new gastrointestinal cancer diagnosis (7.4 percent vs 0.5 percent; hazard ratio [HR], 20.6, 95 percent CI, 15.2–27.8) and new nongastrointestinal cancer diagnosis (3.8 percent vs 3.1 percent; HR, 1.70, 1.20–2.40).

Additionally, genitourinary bleeding bore a higher risk of new genitourinary cancer diagnosis (15.8 percent vs 0.8 percent; HR, 32.5, 24.7–42.9), while urinary bleeding showed an association with higher risk of new urinary cancer diagnosis (14.2 percent vs 0.2 percent; HR, 98.5, 68.0–142.7).

Finally, nongastrointestinal, nongenitourinary bleeding was associated with a threefold higher hazard of nongastrointestinal, nongenitourinary cancers (4.4 percent vs 1.9 percent; HR, 3.02, 2.32–3.91).

Researchers believe that the present data should prompt a careful search for undiagnosed cancer in patients receiving antithrombotic drugs who develop gastrointestinal and genitourinary bleeding, even when the bleeding is minor.

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Most Read Articles
01 Nov 2019
Women with hypertensive disorders of pregnancy, especially pre-eclampsia, are at heightened risk of developing cardiovascular disorder and chronic hypertension, with the risk becoming apparent soon after pregnancy, a study has found.
Roshini Claire Anthony, 29 May 2019

Gestational diabetes and abnormal glucose levels in pregnancy, as determined with an oral glucose challenge test (OGCT) at 24–28 weeks gestation, could signal a future risk of cardiovascular disease (CVD)*, according to a recent study.

07 Jul 2019
Plasma creatinine kinase activity, measure during early pregnancy, influences blood pressure during pregnancy and contributes to severe gestational hypertension diagnosed before 34 weeks of gestation, according to a recent study. There is no association between creatinine kinase and other hypertensive disorders during pregnancy.
Pank Jit Sin, 16 Oct 2019
While a diagnosis of cancer is often met with concern and devastation, the same is barely true for heart failure. However, the mortality rate for those suffering from heart failure is worse than some common cancers, such as prostate and breast cancers.