Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
Audrey Abella, 16 Sep 2020
The final results of EVAPORATE* reinforce the plaque-regressing potential of icosapent ethyl (IPE) in patients on statins for elevated triglycerides.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.

Bleeding linked to increased cancer risk in atherosclerotic patients on antithrombotics

08 Oct 2019

Any gastrointestinal or genitourinary bleeding carries a 20–30-fold higher hazard for new cancer diagnosis in the respective organ systems in patients with atherosclerosis receiving antithrombotic drug treatment, as shown in a recent study.

The study used data from the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) trial and included 27,395 patients (mean age, 68 years; 21 percent) new cancers diagnosed in relation to gastrointestinal or genitourinary bleeding among patients enrolled in the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) trial.

During a mean follow-up of 23 months, any (major or minor) bleeding occurred in 2,678 patients (9.8 percent), among whom 257 (9.9 percent) were subsequently diagnosed with cancer.

Gastrointestinal bleeding was associated with an increased risk of new gastrointestinal cancer diagnosis (7.4 percent vs 0.5 percent; hazard ratio [HR], 20.6, 95 percent CI, 15.2–27.8) and new nongastrointestinal cancer diagnosis (3.8 percent vs 3.1 percent; HR, 1.70, 1.20–2.40).

Additionally, genitourinary bleeding bore a higher risk of new genitourinary cancer diagnosis (15.8 percent vs 0.8 percent; HR, 32.5, 24.7–42.9), while urinary bleeding showed an association with higher risk of new urinary cancer diagnosis (14.2 percent vs 0.2 percent; HR, 98.5, 68.0–142.7).

Finally, nongastrointestinal, nongenitourinary bleeding was associated with a threefold higher hazard of nongastrointestinal, nongenitourinary cancers (4.4 percent vs 1.9 percent; HR, 3.02, 2.32–3.91).

Researchers believe that the present data should prompt a careful search for undiagnosed cancer in patients receiving antithrombotic drugs who develop gastrointestinal and genitourinary bleeding, even when the bleeding is minor.

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Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
Audrey Abella, 16 Sep 2020
The final results of EVAPORATE* reinforce the plaque-regressing potential of icosapent ethyl (IPE) in patients on statins for elevated triglycerides.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.