Most Read Articles
Roshini Claire Anthony, 04 Apr 2019

In addition to an intensive weight loss programme, the use of continuous positive airway pressure (CPAP) could improve absolute weight loss in individuals with obesity and obstructive sleep apnoea (OSA), according to a study presented at ENDO 2019.

4 days ago
The ketogenic and Modified Atkin’s diets are effective treatments for children with refractory epilepsy of genetic aetiology, a new study suggests.
5 days ago
Extremely premature neonates who have been exposed to pre-eclampsia in utero are at high risk of developing severe respiratory distress syndrome and severe bronchopulmonary dysplasia, according to a study.
Pearl Toh, 3 days ago
A contraceptive vaginal system (Annovera) releasing a combination of segesterone acetate and ethinyl estradiol (SA/EE) effectively inhibits ovulation up to a year even at low systemic levels of SA, reports a review study presented at ENDO 2019.

Bleeding during DAPT more likely in patients on haemodialysis

5 days ago

Dual-antiplatelet therapy (DAPT) may increase the risk of bleeding and ischaemic events in patients with second-generation drug-eluting stent (2nd-DES) implants undergoing haemodialysis (HD), a recent study suggests.

Researchers retrospectively analysed 620 patients who underwent percutaneous coronary intervention with 2nd-DES implantation. Most patients (n=518; mean age, 71.4±10.5 years; 71.4 percent male) were not undergoing HD, while the remaining 102 (mean age 68.4±10.4 years; 64.7 percent male) were. The Bleeding Academic Research Consortium (BARC) criteria was used to evaluate the primary outcome of bleeding events during DAPT.

A total of 76 patients (12.3 percent) experienced bleeding events. Specifically, BARC type 2, 3 and 5 events were reported in 21 (3.4 percent), 46 (7.4 percent) and nine (1.5 percent) participants, respectively. The likelihood of such bleeding events occurring was significantly higher in those undergoing HD (hazard ratio [HR], 2.50; 95 percent CI, 1.49–4.06; p<0.001).

The same was true for BARC type 3 or 5 (HR, 2.83; 1.55–4.95). On the other hand, major bleeding events, such as intracranial and gastrointestinal bleeding, were comparable between HD and non-HD patients.

Multivariate Cox hazards models confirmed that HD was a significant predictor of the occurrence of major bleeding events (HR, 1.83; 1.03–3.16; p=0.04).

Moreover, researchers also found a significant negative effect of HD on the risk of all-cause mortality (HR, 2.61; 1.79–3.75; p<0.001) and major adverse cardiovascular and cerebrovascular events postdischarge (53.9 percent vs 29.3 percent; p<0.001). For instance, cardiac death (HR, 6.20; 3.18–12.1; p<0.001) and target vessel revascularization (HR, 2.60; 1.48–4.36; p=0.001) were significantly more likely in patients undergoing HD.

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Most Read Articles
Roshini Claire Anthony, 04 Apr 2019

In addition to an intensive weight loss programme, the use of continuous positive airway pressure (CPAP) could improve absolute weight loss in individuals with obesity and obstructive sleep apnoea (OSA), according to a study presented at ENDO 2019.

4 days ago
The ketogenic and Modified Atkin’s diets are effective treatments for children with refractory epilepsy of genetic aetiology, a new study suggests.
5 days ago
Extremely premature neonates who have been exposed to pre-eclampsia in utero are at high risk of developing severe respiratory distress syndrome and severe bronchopulmonary dysplasia, according to a study.
Pearl Toh, 3 days ago
A contraceptive vaginal system (Annovera) releasing a combination of segesterone acetate and ethinyl estradiol (SA/EE) effectively inhibits ovulation up to a year even at low systemic levels of SA, reports a review study presented at ENDO 2019.