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Bladder debris predicts positive urine culture in children

08 Feb 2018

In paediatric patients undergoing urological evaluation, the presence of bladder debris, regardless of severity, on ultrasound appears to predict a positive urine culture, a recent study has shown.

Researchers performed a retrospective review of 445 paediatric patients (mean age 5.8±4.1 years; 85 percent female), 20 percent of whom (n=87) tested positive for the urine culture. The overall rate of bladder debris was 22 percent (n=96).

Bladder debris was significantly more common in females, of whom 23 percent were positive. In comparison, only 12 percent of males had bladder debris (p=0.04).

Bladder debris was an acceptable predictive factor for positive urine culture, with a sensitivity and specificity of 52 and 86 percent, respectively. Almost half (47 percent) of those with bladder debris had positive urine cultures, significantly higher than the 12 percent of those without bladder debris (p<0.001).

The relative risk of a positive urine culture was significantly higher when bladder debris was present (3.90; 95 percent CI, 2.73–5.55). Despite a difference in the rate of bladder debris, males and females had statistically comparable rates of positive cultures. The presence of hydronephrosis (p=0.41) or vesicoureteral reflux (p=0.87) did not significantly alter the relationship between bladder debris and positive urine cultures.

In a subgroup analysis by degree, 40 participants were found to have severe bladder debris, 53 percent (n=21) of whom had positive urine cultures. In these patients, the sensitivity and specificity of bladder debris were 24 and 95 percent, respectively, while the relative risk of a positive urine culture was 3.22.

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Most Read Articles
29 Nov 2018
Pulmonary hypertension (PH) is associated with underlying risk factors in children with congenital hyperinsulinism (HI) treated with diazoxide, reports a study. Other adverse events, however, do not show any identifiable risk profile.
14 Mar 2017
Levels of serum proteins, particularly the leucine-rich alpha-2-glycoprotein 1 (LRG1), can be used as biomarkers for the diagnosis of Kawasaki disease (KD) and accurate identification of its phases, a new proteomic study reveals.
18 Jan 2019
Azithromycin treatment in children with recurrent asthma-like symptoms acutely disrupts gut microbiota composition, a recent study has found.
01 Sep 2016
Salmeterol/fluticasone exhibits comparable serious asthma-related event risk with that of fluticasone alone in children with asthma, a prospective study shows.