Most Read Articles
Roshini Claire Anthony, 09 Oct 2020

The risk of falls and subsequent injuries (eg, fractures) may be elevated in individuals with diabetes compared with the general population, according to a nationwide cohort study from Denmark.

Audrey Abella, 10 Sep 2020
Interim results of REGENERATE* trial highlight the ability of experimental noninvasive tests to evaluate treatment response in adults with NASH** and advanced liver fibrosis who are receiving obeticholic acid (OCA).
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Jairia Dela Cruz, 23 Sep 2020
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Black seed oil eases doxorubicin-induced cardiac side effects in acute lymphoblastic leukaemia

31 Aug 2020
Childhood cancers show a marked increase of 13% worldwide with leukaemia affecting a third of the cases involving children below 15 years old.

Treatment with black seed oil results in better systolic function, thus improving doxorubicin-induced cardiac toxicity in children with acute lymphoblastic leukaemia, a study has shown.

Forty children with acute lymphoblastic leukaemia participated in this study. Twenty patients received doxorubicin therapy and black seed oil 80 mg/kg/dose divided into three doses starting at the same time as doxorubicin infusion therapy initiation and continued for 1 week after each doxorubicin dose (group 1), and the remaining 20 were administered doxorubicin and placebo for 1 weeks after each doxorubicin dose (group 2).

These children also underwent conventional echo-Doppler measures of left ventricular systolic and diastolic functions and pulsed wave tissue Doppler of lateral mitral annulus.

The parameters of electrocardiograph, including ST segment and QT interval either before or after doxorubicin therapy, did not show any significant differences. No significant differences were found as well in echocardiographic parameters between group 1 and group 2 before therapy.

Furthermore, there were nonsignificant changes in parameters of diastolic function (E/A ratio or e/a ratio) following doxorubicin therapy in groups 1 and 2. However, significant reductions were seen in parameters of systolic function (EF, FS, and s wave) after doxorubicin therapy, which was more prominent in group 2 than in group 1.

“Multicentre studies are recommended to be done before we can recommend the use of black seed oil as an adjuvant therapy in patients with acute lymphoblastic leukaemia under doxorubicin-based treatment protocol,” the authors said.

A well-established chemotherapeutic agent included in treatment protocols of acute lymphoblastic leukaemia, doxorubicin is often limited by its cardiotoxic side effects.

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Most Read Articles
Roshini Claire Anthony, 09 Oct 2020

The risk of falls and subsequent injuries (eg, fractures) may be elevated in individuals with diabetes compared with the general population, according to a nationwide cohort study from Denmark.

Audrey Abella, 10 Sep 2020
Interim results of REGENERATE* trial highlight the ability of experimental noninvasive tests to evaluate treatment response in adults with NASH** and advanced liver fibrosis who are receiving obeticholic acid (OCA).
Rachel Soon, 28 Aug 2020
MOH Director-General Tan Sri Dato' Seri Dr Noor Hisham Abdullah speaks about NHMS 2019 and pharmacists' roles in combating NCDs among Malaysians.
Jairia Dela Cruz, 23 Sep 2020
The combination of pitavastatin and fenofibrate appears to have superior effect on non-high-density lipoprotein cholesterol (non–HDL-C), as well as other lipids, compared with a statin alone in high-risk patients with mixed dyslipidemia, according to a study.