Most Read Articles
Roshini Claire Anthony, Yesterday

Many pregnant women may not be getting adequate nutrition as advised by dietary guidelines, researchers of an Australian study found.

6 days ago
The types of bariatric surgery differentially affect the risk of developing acute pancreatitis postoperatively, such that the risk is greater in patients who undergo vertical sleeve gastrectomy vs Roux-en-Y gastric bypass surgery, according to a study. Risk factors include younger age and presence of gallstones.
4 days ago
Misoprostol promotes the healing of small bowel ulcers in aspirin users whose condition is complicated by small bowel bleeding, reports a recent trial.
Jairia Dela Cruz, 5 days ago
An adjuvant trastuzumab treatment course shortened to 9 weeks has failed to demonstrate noninferiority to the standard 1-year course in terms of disease-free survival in breast cancer patients, although the shortened course confers benefits for the risk of severe cardiac toxicity, according to the results of the phase III randomized Short-HER study.

Biologics therapy in rheumatoid arthritis may be tapered successfully

04 Oct 2018

Biologics therapy can be successfully tapered in most rheumatoid arthritis (RA) patients who have achieved sustained remission, especially in subgroups of male patients, those with exposure to a maximum of one previous biological disease-modifying antirheumatic drug (bDMARD), and those with low baseline inflammation or damage score, according to 2-year data from a recent study.

The study included 143 RA patients, among whom 91 percent received tumour necrosis factor (TNF) inhibitors and the remaining 9 percent non-TNF inhibitors. Sustained disease activity score (DAS28-CRP) was 2.6, and no radiographic progression was documented in the previous year.

Treatment with bDMARD was reduced to two-thirds of standard dose at baseline, half after 16 weeks and discontinued after 32 weeks. Tapering was ceased in patients who developed flares (defined as either DAS28-CRP 2.6 and change in DAS28-CRP 1.2 from baseline, or erosive progression on X-ray and/or MRI), with treatment escalated to the previous dose level.

At the 2-year follow-up, bDMARDs were successfully tapered in 87 patients (62 percent), with 26 (18 percent) receiving two-thirds of standard dose, 39 (28 percent) half dose and 22 (16 percent) having discontinued.

Median change in DAS28-CRP was 0.1, while the mean change in Total-Sharp-Score was 0.01. Nine patients (7 percent) had radiographic progression.

Successful tapering was independently associated with the following factors: ≤1 previous bDMARD, male gender, low baseline MRI combined inflammation score or combined damage score. Meanwhile, successful discontinuation was predicted by negative immunoglobulin M rheumatoid factor.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Rheumatology digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, Yesterday

Many pregnant women may not be getting adequate nutrition as advised by dietary guidelines, researchers of an Australian study found.

6 days ago
The types of bariatric surgery differentially affect the risk of developing acute pancreatitis postoperatively, such that the risk is greater in patients who undergo vertical sleeve gastrectomy vs Roux-en-Y gastric bypass surgery, according to a study. Risk factors include younger age and presence of gallstones.
4 days ago
Misoprostol promotes the healing of small bowel ulcers in aspirin users whose condition is complicated by small bowel bleeding, reports a recent trial.
Jairia Dela Cruz, 5 days ago
An adjuvant trastuzumab treatment course shortened to 9 weeks has failed to demonstrate noninferiority to the standard 1-year course in terms of disease-free survival in breast cancer patients, although the shortened course confers benefits for the risk of severe cardiac toxicity, according to the results of the phase III randomized Short-HER study.