Most Read Articles
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
6 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 5 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Pearl Toh, 25 Jun 2020
The type of face mask matters, in addition to sterilization method, in influencing subsequent filtration efficiency after sterilization process for reuse, a new study finds.

Biologics therapy in rheumatoid arthritis may be tapered successfully

04 Oct 2018

Biologics therapy can be successfully tapered in most rheumatoid arthritis (RA) patients who have achieved sustained remission, especially in subgroups of male patients, those with exposure to a maximum of one previous biological disease-modifying antirheumatic drug (bDMARD), and those with low baseline inflammation or damage score, according to 2-year data from a recent study.

The study included 143 RA patients, among whom 91 percent received tumour necrosis factor (TNF) inhibitors and the remaining 9 percent non-TNF inhibitors. Sustained disease activity score (DAS28-CRP) was 2.6, and no radiographic progression was documented in the previous year.

Treatment with bDMARD was reduced to two-thirds of standard dose at baseline, half after 16 weeks and discontinued after 32 weeks. Tapering was ceased in patients who developed flares (defined as either DAS28-CRP 2.6 and change in DAS28-CRP 1.2 from baseline, or erosive progression on X-ray and/or MRI), with treatment escalated to the previous dose level.

At the 2-year follow-up, bDMARDs were successfully tapered in 87 patients (62 percent), with 26 (18 percent) receiving two-thirds of standard dose, 39 (28 percent) half dose and 22 (16 percent) having discontinued.

Median change in DAS28-CRP was 0.1, while the mean change in Total-Sharp-Score was 0.01. Nine patients (7 percent) had radiographic progression.

Successful tapering was independently associated with the following factors: ≤1 previous bDMARD, male gender, low baseline MRI combined inflammation score or combined damage score. Meanwhile, successful discontinuation was predicted by negative immunoglobulin M rheumatoid factor.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Rheumatology digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
6 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 5 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Pearl Toh, 25 Jun 2020
The type of face mask matters, in addition to sterilization method, in influencing subsequent filtration efficiency after sterilization process for reuse, a new study finds.