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13 Jul 2019
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Biologics therapy in rheumatoid arthritis may be tapered successfully

04 Oct 2018

Biologics therapy can be successfully tapered in most rheumatoid arthritis (RA) patients who have achieved sustained remission, especially in subgroups of male patients, those with exposure to a maximum of one previous biological disease-modifying antirheumatic drug (bDMARD), and those with low baseline inflammation or damage score, according to 2-year data from a recent study.

The study included 143 RA patients, among whom 91 percent received tumour necrosis factor (TNF) inhibitors and the remaining 9 percent non-TNF inhibitors. Sustained disease activity score (DAS28-CRP) was 2.6, and no radiographic progression was documented in the previous year.

Treatment with bDMARD was reduced to two-thirds of standard dose at baseline, half after 16 weeks and discontinued after 32 weeks. Tapering was ceased in patients who developed flares (defined as either DAS28-CRP 2.6 and change in DAS28-CRP 1.2 from baseline, or erosive progression on X-ray and/or MRI), with treatment escalated to the previous dose level.

At the 2-year follow-up, bDMARDs were successfully tapered in 87 patients (62 percent), with 26 (18 percent) receiving two-thirds of standard dose, 39 (28 percent) half dose and 22 (16 percent) having discontinued.

Median change in DAS28-CRP was 0.1, while the mean change in Total-Sharp-Score was 0.01. Nine patients (7 percent) had radiographic progression.

Successful tapering was independently associated with the following factors: ≤1 previous bDMARD, male gender, low baseline MRI combined inflammation score or combined damage score. Meanwhile, successful discontinuation was predicted by negative immunoglobulin M rheumatoid factor.

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Most Read Articles
13 Jul 2019
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 6 days ago
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from the large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
6 days ago
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
Tristan Manalac, Yesterday
In patients with ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PPCI), admission Killip classification and creatinine and troponin levels are important cardiac mortality predictors, according to a recent Singapore study.