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01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
2 days ago
Among patients with moderate-to-severe psoriasis, the use of biologics appears to lower the risk of being hospitalized for the novel coronavirus disease (COVID-19), a new study has found.

Biologics cut mortality risk in psoriasis regardless of treatment duration

19 Dec 2020

In patients with moderate-to-severe psoriasis, biologic agents seem to reduce mortality risk regardless of treatment duration, a recent study has found. Methotrexate, on the other hand, only shows a similar efficacy when used for at least a year.

The researchers performed a nested case-control analysis, where cases were defined as psoriasis patients who died. Controls were matched 1:4 in terms of age, race, sex, and geographic region. Methotrexate, tumour necrosis factor α inhibitors (TNFI), and ustekinumab were the medications evaluated. Exposure was defined as taking at least 1 dose within 3 months of death.

Of the 12,090 initial participants, 341 died and were identified as cases (mean age, 66.43±11.93 years; 60.41 percent male); 1,364 controls (mean age, 66.04±11.57 years; 60.41 percent male) were included.

Treatment with biologics (TNFI and ustekinumab) in the last 91 days significantly protected against all-cause mortality, and such an effect was apparent even when patients had been taking the medication for 1 day to <1 year (odds ratio [OR], 0.08, 95 percent confidence interval [CI], 0.03–0.23) or for ≥1 year (OR, 0.09, 95 percent CI, 0.06–0.13).

Methotrexate, on the other hand, could significantly reduce the risk of death only when it was being taken ≥1 year (OR, 0.08, 95 percent CI, 0.02–0.28).

TNFI and ustekinumab similarly showed strong suppressive effects against the risk of cardiovascular mortality or deaths due to other causes, regardless of treatment duration; methotrexate remained effective only when taken for longer periods of time.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
2 days ago
Among patients with moderate-to-severe psoriasis, the use of biologics appears to lower the risk of being hospitalized for the novel coronavirus disease (COVID-19), a new study has found.