Most Read Articles
5 days ago
Being overweight or obese in adolescence appears to increase the risk of papillary thyroid cancer in adulthood, a recent study has shown.
Yesterday
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 20 hours ago
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
5 days ago
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Biologics combo therapy safe in children with IBD

22 Feb 2020
Biosimilar versus Generic: How similar are they?

Combining two biological agents for the treatment of inflammatory bowel disease (IBD) appears to be safe in children, according to a study.

This retrospective study examined nine eligible patients (median age, 16 years) who were being treated for IBD at Children’s Mercy Kansas City and were given a combination of two biologics concurrently for medically refractory disease. The researchers reviewed charts of patients to obtain demographics, Paris classification, extraintestinal manifestations, concomitant morbidities, drug therapy, surgeries, disease activity scores, outcomes and adverse events related to therapy.

Of the patients, eight were Caucasians and one was African American. Crohn’s disease (CD) was diagnosed in eight patients, and ulcerative colitis (UC) was initially detected in one child but was later found to be CD. Coeliac disease was diagnosed in two patients, growth failure in two, arthritis in one and sacroiliitis in one. In addition, two children had ileo-anal pouch and one had recurrent macrophage activating syndrome.

Symptoms suggesting the necessity of treatment were as follows: partially responsive luminal disease (n=7), pouchitis (n=2), perianal fistulizing disease (n=2) and sacroiliitis (n=1). When combination therapy was initiated, five patients were already receiving an immunomodulator. One patient was treated with Anakinra and infliximab, while the rest received the combination of either infliximab or adalimumab with vedolizumab.

Remission occurred in four patients, partial response in four and improvement in growth only in one. However, two patients were unresponsive. Furthermore, staphylococcal skin infection developed in one child, but no other treatment-related adverse event was reported.

“Further studies are needed to determine the utility of this approach,” the researchers said.

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Most Read Articles
5 days ago
Being overweight or obese in adolescence appears to increase the risk of papillary thyroid cancer in adulthood, a recent study has shown.
Yesterday
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 20 hours ago
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
5 days ago
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).