Most Read Articles
Rachel Soon, 5 days ago

On 8 August, the first town hall held by the Ministry of Health (MOH) with members of the pharmacy profession took place in Putrajaya. Over 500 pharmacists from across the country and from different areas of practice—community and hospital, public and private, academy and industry—converged to fill the auditorium for the chance to engage in direct dialogue with MOH.

Stephen Padilla, 6 days ago
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
3 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.

Biologic use lower in RA patients who are older, with more comorbidities

02 May 2019

Initiation of biologic therapy is less frequent among patients with rheumatoid arthritis (RA) who are older, nonwhite and have more comorbidities, according to a recent study. Biologics may be avoided in older and sicker patients due to safety concerns, but glucocorticoid use is similar regardless of age and more common in patients with comorbidities, with implications for patient outcomes.

Methotrexate (MTX) was initiated in 17,415 patients, among whom 3,262 received biologic therapy within 2 years (2-year incidence, 20.6 percent). Adjusted analyses showed a substantially lower use of biologics in older patients (for patients ≥80 vs <50 years: adjusted hazard ratio [aHR], 0.20; 95 percent CI, 0.16–0.26) and those with more comorbidities (for Charlson score ≥3 vs <3: aHR, 0.79; 0.72–0.87).

Biologic use was also less frequent among patients with heart failure (aHR, 0.68; 0.54–0.84), cancer (aHR, 0.78; 0.66–0.92) or who were nonwhite (aHR, 0.79; 0.72–0.87). On the other hand, baseline and persistent glucocorticoid use were similar across age groups and more frequent in patients with higher comorbidities.

The investigators identified RA patients receiving a first-ever prescription of MTX, requiring ≥6 months of baseline data, using national US Veteran’s Affairs databases 2005–2016. They examined predictors of biologic therapy initiation within 2 years of initiating MTX and factors associated with baseline and persistent glucocorticoid use at 6–12 months using multivariable models.

“Biologic therapies can improve disease control for patients with RA but may be both overused and underused,” the investigators said.

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Most Read Articles
Rachel Soon, 5 days ago

On 8 August, the first town hall held by the Ministry of Health (MOH) with members of the pharmacy profession took place in Putrajaya. Over 500 pharmacists from across the country and from different areas of practice—community and hospital, public and private, academy and industry—converged to fill the auditorium for the chance to engage in direct dialogue with MOH.

Stephen Padilla, 6 days ago
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
3 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.