Most Read Articles
09 Dec 2016
All patients with acne are potentially at risk of scarring. Professor Goh Chee Leok addresses this issue by focussing on preventing the development of scars in his talk at the 41st Annual Meeting of the Dermatological Society of Malaysia held in Kuching, Sarawak.
25 Aug 2016
Peeling treatments with lactobionic acid, corundum microdermabrasion, or a combination of both can significantly decrease sebum secretion in patients with acne vulgaris, a new study finds.
06 Jun 2016

The recent Paediatrics in Practice (PIP) 2016 held recently in Selangor was a success. On top of the launch of a locally published atlas, the conference also featured the introduction of DEBRA (Dystrophic Epidermolysis Bullosa Research Association), various presentations, a workshop and panel discussion on paediatric skin diseases by prominent specialists such as Dr. Tang Jyh Jong, Dr. Tan Wooi Chiang, Dr. Chan Lee Chin, Dr. Sabeera Begum and Dr. Leong Kin Fon. MIMS Doctor spoke to Dr. Thiyagar Nadarajaw, paediatrician and adolescent medicine specialist and Leong, a consultant paediatric dermatologist at the Kuala Lumpur Hospital about the PIP workshop and their thoughts on the atlas.

Biologic therapies pose risk of reactivation in psoriasis patients with chronic HBV infection

07 Jul 2017

The risk for viral reactivation with biologic therapies is negligible in low-risk patients without hepatitis seropositive for hepatitis B or C virus (HBV and HCV, respectively) core antibody, a recent study has found. However, biologic therapies pose a significant risk in patients with chronic HBV infection, stressing the need for antiviral prophylaxis.

Researchers assessed the safety of biologic therapies in psoriasis patients seropositive for HBV or HCV in this retrospective cohort study. They evaluated the clinical and laboratory data of 30 patients undergoing biologic therapy who were seropositive for HBV or HCV, and conducted a systematic review.

In addition, treatment duration and antiviral prophylaxis were recorded. Hepatitis and viral reactivation during therapy were the primary outcomes.

Serology showed past HBV infection in 17 patients, isolated core antibody in eight patients, HCV infection in four patients and chronic HBV infection in one patient. During a mean follow-up of 4.85 years, none of the patients experienced hepatitis or viral reactivation.

In the systematic review of literature, a total of 49 studies were included. These comprised 312 patients followed for a mean of 30.9 months.

Viral reactivation occurred less in patients who were seropositive for core antibody (two out of 175; yearly rate, 0.32 percent) and in those with HCV infection (three out of 97; yearly rate, 2.42 percent) compared with patients with chronic HBV infection (eight out of 40; yearly rate, 13.92 percent). Antiviral prophylaxis were administered in three of these eight patients with reactivated HBV infection.

The study was limited by the analysis of heterogeneous studies that evaluated different biologic therapies, according to researchers.

Editor's Recommendations
Most Read Articles
09 Dec 2016
All patients with acne are potentially at risk of scarring. Professor Goh Chee Leok addresses this issue by focussing on preventing the development of scars in his talk at the 41st Annual Meeting of the Dermatological Society of Malaysia held in Kuching, Sarawak.
25 Aug 2016
Peeling treatments with lactobionic acid, corundum microdermabrasion, or a combination of both can significantly decrease sebum secretion in patients with acne vulgaris, a new study finds.
06 Jun 2016

The recent Paediatrics in Practice (PIP) 2016 held recently in Selangor was a success. On top of the launch of a locally published atlas, the conference also featured the introduction of DEBRA (Dystrophic Epidermolysis Bullosa Research Association), various presentations, a workshop and panel discussion on paediatric skin diseases by prominent specialists such as Dr. Tang Jyh Jong, Dr. Tan Wooi Chiang, Dr. Chan Lee Chin, Dr. Sabeera Begum and Dr. Leong Kin Fon. MIMS Doctor spoke to Dr. Thiyagar Nadarajaw, paediatrician and adolescent medicine specialist and Leong, a consultant paediatric dermatologist at the Kuala Lumpur Hospital about the PIP workshop and their thoughts on the atlas.