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Bimatoprost-brimonidine-timolol eye drops effectively lower IOP in POAG, OHT patients

Jairia Dela Cruz
30 Mar 2020

A triple fixed combination (TFC) of bimatoprost 0.01%/brimonidine 0.15%/timolol 0.5% ophthalmic solution provides superior intraocular pressure (IOP)-lowering effects compared with a dual fixed combination (DFC) of brimonidine 0.2%/timolol 0.5% in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT), according to the results of a phase III study.

“An acceptable tolerability profile was observed through 12 months of use of TFC, offering an effective therapeutic option in patients with POAG or OHT who require multiple medications to control their IOP,” the investigators said.

The analysis included 185 patients who had been randomized to receive TFC (n=90) or DFC (n=95) twice daily in each eye for 3 months. All patients had a baseline IOP of 23–34 mm Hg in both eyes. Treatment was prolonged for up to 12 months in those who chose to do so.

At week 12, results for the primary efficacy outcome of change from baseline in mean IOP in the worse eye favoured TFC (difference vs DFC, ─2.17 mm Hg, 95 percent confidence interval [CI], ─3.12 to ─1.22), with TFC demonstrating superiority over DFC at every visit (weeks 1, 2, 4, 8 and 12; p<0.001). [Clin Ther 2020;42:263-275]

Treatment-related adverse events (AEs) occurred with greater frequency in the TFC than in the DFC arm (72.2 percent vs 53.7 percent; p=0.009), especially conjunctival hyperaemia (47.8 percent vs 23.2 percent; p<0.001), consistent with the additional presence of bimatoprost in TFC. However, these events were mostly mild, and none were serious. There was no significant between-group difference observed in the number of treatment discontinuations at week 12 (12.2 percent vs 7.4 percent; p=0.266).

Similar results were obtained from the 12-month masked-extension safety data. The percentage of patients with treatment-related AEs were markedly higher with TFC than with DFC (82.2 percent vs 65.3 percent; p=0.009).

“The thee active ingredients in TFC are known to reduce IOP via complementary mechanisms of action, and the current fixed combination requires the administration of only one drop from the same bottle of ophthalmic solution twice per day,” the investigators said.

In comparison, the same regimen of bimatoprost, brimonidine and timolol used as concurrent monotherapies requires up to six administrations of drops from three different bottles per day, and three or more administrations from multiple bottles per day if DFCs are available, they added.

Therefore, the efficacy and safety of TFC reported in the current trial hold clinical relevance, given that the need for using multiple bottles of different medications per day increases treatment burden for glaucoma patients and that up to 80 percent of them may struggle with adherence to their medication regimen because of the inconvenience associated with multiple eye drop instillation, among other factors, the investigators pointed out. [Optom Vis Sci 2013;90:883-897; Ophthalmology 2015;122:1308-1316; BMC Ophthalmol 2010;10:1]

“The effectiveness of fixed-combination products such as once-daily TFC should not, however, undermine the importance of adherence, and clinicians should counsel their patients regularly on the merit of using their medications as prescribed,” they added.

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Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Pearl Toh, 3 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
2 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, Yesterday

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.