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Big waist ups low physical function risk in adults with knee OA

15 Oct 2020

A growing waistline increases the risk of incident low physical function in the following year among adults with knee osteoarthritis (OA), suggests a recent study. Maintaining waist circumference (WC) may prevent the development of low physical function.

The investigators used data from the Osteoarthritis Initiative, measuring change in WC from study enrolment (0 month) to the 96-month visit and classifying as increase (≥5-cm gain) or maintain (<5-cm gain). The World Health Organization (WHO) risk category was identified based on WC at study enrolment as either large (males ≥102 cm; females ≥88 cm) or small (males <102 cm; females <88 cm).

Incident low physical function was defined as ≥28 Western Ontario and McMaster Universities Osteoarthritis Index physical function subscale. Risk ratios were calculated and adjusted for potential confounders to assess the association of the 8-year change in WC with the risk of low physical function. The investigators repeated the analyses stratified by the WHO disease risk category.

Adults in the increased WC group had a 43-percent (95 percent confidence interval [CI], 1.04–1.96) higher risk of incident low physical function than those in the maintained WC group.

Participants with a large WC at baseline who increased WC had a 55-percent (95 percent CI, 1.00–2.37) higher risk of incident low physical function than those who maintained their WC. Furthermore, adults with a small WC at baseline who increased WC had a 97-percent (95 percent CI, 0.84–4.63) higher risk compared to those who maintained WC.

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Most Read Articles
2 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
Yesterday
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 5 days ago
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).