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Big waist ups low physical function risk in adults with knee OA

15 Oct 2020

A growing waistline increases the risk of incident low physical function in the following year among adults with knee osteoarthritis (OA), suggests a recent study. Maintaining waist circumference (WC) may prevent the development of low physical function.

The investigators used data from the Osteoarthritis Initiative, measuring change in WC from study enrolment (0 month) to the 96-month visit and classifying as increase (≥5-cm gain) or maintain (<5-cm gain). The World Health Organization (WHO) risk category was identified based on WC at study enrolment as either large (males ≥102 cm; females ≥88 cm) or small (males <102 cm; females <88 cm).

Incident low physical function was defined as ≥28 Western Ontario and McMaster Universities Osteoarthritis Index physical function subscale. Risk ratios were calculated and adjusted for potential confounders to assess the association of the 8-year change in WC with the risk of low physical function. The investigators repeated the analyses stratified by the WHO disease risk category.

Adults in the increased WC group had a 43-percent (95 percent confidence interval [CI], 1.04–1.96) higher risk of incident low physical function than those in the maintained WC group.

Participants with a large WC at baseline who increased WC had a 55-percent (95 percent CI, 1.00–2.37) higher risk of incident low physical function than those who maintained their WC. Furthermore, adults with a small WC at baseline who increased WC had a 97-percent (95 percent CI, 0.84–4.63) higher risk compared to those who maintained WC.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
4 days ago
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.