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Pearl Toh, 07 Aug 2018
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BICAMS suitable for measuring cognition during multiple sclerosis relapse

10 Jun 2018
Multiple Sclerosis (MS) is a debilitating disease, in which nerve damage affects communications between the brain and body. HSCT could provide the therapeutic answer for MS patients.

Use of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) is suitable for a quick assessment of patient cognition during multiple sclerosis (MS) relapse, a recent study has shown.

The study included 120 MS patients (60 with relapsing and 30 with stable disease) and 30 healthy controls. All groups were matched according to demographic and disease characteristics.

Relapsing and stable MS patients consistently had lower mean BICAMS scores than healthy controls: Symbol Digit Modalities Test (SDMT; 40.18±11.42 and 46.60±11.54 vs 53.83±8.91; p<0.001), Brief Visuospatial Memory Test-Revised (BVMT-R; 22.57±6.07 and 25.23±5.66 vs 29.03±4.22; p<0.001) and California Verbal Learning Test, II edition (CVLT-II; 52.02±9.61 and 54.80±9.40 vs 66.97±4.68; p<0.001).

Scores during relapse and 1 and 3 months after relapse were then compared. Scores were significantly higher 1 month after relapse (SDMT: 46.20±12.28; BVMT-R: 26.30±4.56; CVLT-II: 58.45±8.36). Only scores in the CVLT-II showed further significant improvement between 1 and 3 months.

“Assessing the results after relapse, we found that the results of all of the tests were significantly higher at 1 month after relapse than during relapse and that the results of only the verbal memory test were significantly higher at 3 months after relapse than after 1 month,” said researchers.

“Neuropsychological assessment, like physical disability assessment, is important during relapse. BICAMS may be suitable for quick and effective assessment of cognition during relapse,” they added.

For the study, MS patients were eligible for inclusion if they had not been assessed with BICAMS in the past and if they were not taking medications that may affect cognition. One-way analysis of variance was used to compare the means among the three patient groups.

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Most Read Articles
Pearl Toh, 07 Aug 2018
A home-based, self-applied wearable electrocardiogram (ECG) patch facilitates diagnosis of atrial fibrillation (AF) among high-risk individuals, according to the mSToPS* trial.
Roshini Claire Anthony, 2 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

5 days ago

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 3 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.