Most Read Articles
Stephen Padilla, 2 days ago
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
01 Aug 2020
Ensituximab, a chimeric monoclonal antibody targeting a variant of MUC5AC, shows modest clinical activity with good safety profile in patients with refractory colorectal cancer, according to data from a phase II study.
Roshini Claire Anthony, 30 Jul 2020

Frailty may indicate an increased risk of death from COVID-19, results of the COPE* study showed.

Better sleep tied to less knee pain worsening in persons with widespread pain

17 Jul 2020

Improved sleep quality appears to reduce knee pain worsening (KPW) with coexisting widespread pain (WSP), suggests a recent study.

The authors assessed sleep quality and restless sleep using a single item from two validated questionnaires at the 60-month visit of the Multicenter Osteoarthritis Study. They categorized each sleep measure into three levels, with poor/most restless sleep as the reference. Generalized estimating equations were applied in multivariable logistic regression models.

WSP was defined as pain above and below the waist on both sides of the body and axially using a standard homunculus, based on the American College of Rheumatology criteria. Outcomes from 60–84 months were as follows: KPW (defined as minimal clinically important difference in WOMAC pain), prevalent, and incident consistent frequent knee pain.

A total of 4,648 knees from 2,329 participants (body mass index, 30.9 kg/m2) were analysed. The association between sleep quality and KPW was modified by WSP (pinteraction=0.002). Among persons with WSP, those with very good sleep appeared to have lessened KPW (odds ratio, 0.53, 95 percent confidence interval, 0.35–0.78; ptrend<0.001).

In addition, the strongest association of sleep quality was observed in persons with more than eight painful joint sites (ptrend<0.01), but not in those with two or less painful joint sites. Similar results were seen in restless sleep, in the presence of WSP. Moreover, a significant cross-sectional relationship was found between sleep and prevalence of consistent frequent knee pain.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Stephen Padilla, 2 days ago
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
01 Aug 2020
Ensituximab, a chimeric monoclonal antibody targeting a variant of MUC5AC, shows modest clinical activity with good safety profile in patients with refractory colorectal cancer, according to data from a phase II study.
Roshini Claire Anthony, 30 Jul 2020

Frailty may indicate an increased risk of death from COVID-19, results of the COPE* study showed.