Most Read Articles
Roshini Claire Anthony, 5 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
4 days ago
Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.
5 days ago
There appears to be no clear link between pornography use, even at problematic levels, and erectile dysfunction, a recent US study has shown.

Better cardiovascular health tied to lower risk of nonalcoholic fatty liver disease

02 Jan 2019

Increasing cardiovascular health is associated with a lower risk of nonalcoholic fatty liver disease (NAFLD), a new study has shown.

Researchers followed 3,424 adults (mean age 57.3±8.8 years; 73.9 percent female) with no baseline NAFLD for 5 years for the development of the disease. Cardiovascular health metrics included smoking, body mass index (BMI) blood pressure, total cholesterol, fasting glucose and physical activity.

A total of 649 participants (19.0 percent) developed NAFLD, among whom unfavourable baseline metabolic risk profiles were more common. For instance, only 41.5 percent of these participants had ideal baseline BMI, as opposed to 67.4 percent in the group who did not develop NAFLD (p<0.01).

After adjusting for sociodemographic variables, lifestyle behaviours and clinical factors, having ideal BMI at baseline was associated with a significantly lower risk of NAFLD development (odds ratio [OR], 0.40; 95 percent CI, 0.33–0.48). Ideal blood pressure at baseline had the same effect (OR, 0.73; 0.55–0.98).

Moreover, NAFLD risk progressively dropped as the number of ideal cardiovascular metrics at baseline increased (reference: 0–2 ideal metrics; 3–4 metrics: OR, 0.50; 0.41–0.61; 5–6 metrics: OR, 0.34; 0.22–0.51).

At the 5-year follow-up, cardiovascular health deteriorated in 1,373 participants, such that the mean number of ideal metrics dropped from 3.56±1.01 at baseline to 2.23±0.95 at follow-up. Compared to these patients, those whose cardiovascular health was stable (n=1,170; OR, 0.61; 0.49–0.76) or improved (OR, 0.29; 0.21–0.39) showed significantly lower risks of NAFLD development.

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Most Read Articles
Roshini Claire Anthony, 5 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
4 days ago
Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.
5 days ago
There appears to be no clear link between pornography use, even at problematic levels, and erectile dysfunction, a recent US study has shown.