Most Read Articles
Roshini Claire Anthony, 02 Feb 2018

The use of weight loss medications for at least 1 year did little to improve cardiometabolic risk factors in obese adults, according to a systematic review and meta-analysis.

17 Feb 2019
In patients with type 2 diabetes (T2D), sodium-glucose cotransporter 2 (SGLT2) inhibitor monotherapy, particularly canagliflozin, exerts greater effects on weight compared with metformin and dipeptidyl peptidase 4 (DPP-4) inhibitors or gliptins, according to the results of a meta-analysis.
26 Feb 2019
Oral fluoxetine confers beneficial effects in the management of adult and adolescent amblyopia, suggests a recent study.
19 Feb 2019
Preprandial administration of metformin successfully and safely reduces postprandial plasma triglyceride levels, a new study has shown.

Beta-blockers safe for use in ECMO patients

10 Aug 2019

The use of beta-blockers in hypoxaemic patients receiving veno-venous extracorporeal membrane oxygenation (V–V ECMO) safely and modestly increases oxygen saturation, a recent study has found.

Researchers retrospectively examined 33 patients (median age, 49 years; 55 percent male) who received beta-blockers for a median of 4 days while on V–V ECMO. The primary safety outcome was the occurrence of a composite of bradycardia or hypotension requiring intervention, as well as the need for resuscitation, the discontinuation of beta-blockers during the first 5 days and an unexplained spike in serum lactate.

A total of 15 safety events in 13 patients (39 percent) were reported. Majority (n=9) required an increase in norepinephrine dose though only one had to discontinue beta-blocker medication. Other safety endpoints included bradycardia with need for intervention (n=2), new rise in lactate levels (n=2), new septic shock (n=1) and the risk of adverse drug interactions (n=1).

In terms of efficacy, there was a significant increase in oxygen saturation in the first 12 hours after beta-blocker initiation (92 percent to 96 percent; p=0.01) accompanied by a decrease in heart rate (105 to 93 bpm; p<0.01). There were no such changes in lactate levels, norepinephrine dose and mean arterial pressure.

“In our experience, [beta-blocker] therapy was well tolerated and resulted in a significant increase in arterial oxygenation in patients on V-V ECMO,” said researchers. “Future prospective studies should be performed to clarify the benefit of this strategy in this setting.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Pharmacist - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 02 Feb 2018

The use of weight loss medications for at least 1 year did little to improve cardiometabolic risk factors in obese adults, according to a systematic review and meta-analysis.

17 Feb 2019
In patients with type 2 diabetes (T2D), sodium-glucose cotransporter 2 (SGLT2) inhibitor monotherapy, particularly canagliflozin, exerts greater effects on weight compared with metformin and dipeptidyl peptidase 4 (DPP-4) inhibitors or gliptins, according to the results of a meta-analysis.
26 Feb 2019
Oral fluoxetine confers beneficial effects in the management of adult and adolescent amblyopia, suggests a recent study.
19 Feb 2019
Preprandial administration of metformin successfully and safely reduces postprandial plasma triglyceride levels, a new study has shown.