Most Read Articles
Pearl Toh, 15 Apr 2020
Transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic stenosis who are at low surgical risk appears to be safe with low rates of death or disabling stroke at 30 days, according to a study presented at the ACC.20/WCC Virtual Meeting.

Beta-blockers confer short-term mortality protection in ACS patients

13 Mar 2020
Adverse psychological effects caused by beta blockers add on to the depression experienced by many following cardiac surgery.

Beta-blockers are effective short-term interventions for acute coronary syndrome (ACS) patients with left ventricular ejection fraction (LVEF) ≥40 percent, improving in-hospital and 1-month survival, a recent study has found.

Researchers performed a prospective, multicentre cohort study of 2,028 ACS patients (mean age, 60±13 years; 66 percent male) with LVEF ≥40 percent. Outcomes of interest were in-hospital, 6-month and 12-month mortality rates, assessed with respect to the timing of beta-blocker administration (before admission, 24 hours after admission and upon discharge).

Thirty-one in-hospital deaths were reported. Multivariable logistic regression analysis found that the risk for mortality was significantly lower in patients who were on beta-blockers before admission (odds ratio [OR], 0.25, 95 percent confidence interval [CI], 0.09–0.67; p=0.007) or in those who were administered the medication within 24 hours of admission (OR, 0.16, 95 percent CI, 0.08–0.35; p<0.001).

This effect did not appear to be significantly modified by the presence of revascularization or by the type of ACS.

At 1 month after discharge, 18 more deaths were reported, yielding a cumulative mortality rate of 2.4 percent. This appeared to be less likely among those who had been given beta-blockers, an effect that remained significant even after multivariable adjustments (OR, 0.25, 95 percent CI, 0.09–0.67; p=0.006).

The cumulative rates of mortality by 6 and 12 months were 4.8 percent and 7.2 percent, respectively. Notably, researchers found that beta-blockers ceased to be significantly protective against death at these time points.

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Most Read Articles
Pearl Toh, 15 Apr 2020
Transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic stenosis who are at low surgical risk appears to be safe with low rates of death or disabling stroke at 30 days, according to a study presented at the ACC.20/WCC Virtual Meeting.