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Roshini Claire Anthony, 3 days ago

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Belly fat may lead to vertebral fractures

22 Feb 2021

Abdominal obesity contributes to a heightened risk of developing vertebral fracture (VF) in men, a study reports. In women, a large waist circumference (WC) confers a risk increase.

The analysis included 352,095 individuals who were representative of the Korean National Health Insurance System. Participants were aged ≥40 years who underwent health checkups between 2009 and 2012. Abdominal obesity was defined according to the Asian-specific WC cutoff, that is ≥90 cm in men and ≥85 cm in women.

Over 5.5 years of follow-up, a total of 2,030 and 4,968 new cases of VF were recorded in men and women, respectively. Multivariable Cox proportional hazard regression analysis revealed that men with versus without abdominal obesity had an elevated risk of VF (hazard ratio [HR], 1.11, 95 percent confidence interval [CI], 1.01–1.23).

In women, on the other hand, the risk of VF increased accordingly in higher WC groups (ptrend<0.001). Relative to a WC of 80.0–84.9 cm, a WC 85.0–89.9 cm was associated with a 12-percent higher VF risk (HR, 1.12, 95 percent CI, 1.02–1.22), 90.0–94.9 cm with a 19-percent elevation (HR, 1.19, 95 percent CI, 1.08–1.32), and ≥95.0 cm with a 27-percent increase (HR, 1.27, 95 percent CI, 1.12–1.43). Meanwhile, WC <75.0 cm showed a protective association (HR, 0.81, 95 percent CI, 0.75–0.88). The estimates persisted despite stratification by age in women.

In light of the findings, trimming the WC and controlling abdominal obesity may be beneficial in reducing future VF risk.

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Most Read Articles
Roshini Claire Anthony, 3 days ago

The addition of methylprednisolone to standard care* reduced mortality risk in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF), according to a study from China.

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Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Stephen Padilla, 3 days ago
High-flow oxygen is not associated with an increase or a decrease in 30-day mortality, suggesting no benefit in most patients presenting with a suspected acute coronary syndrome (ACS), reports a New Zealand study.